Narciclasine attenuates diet-induced obesity by promoting oxidative metabolism in skeletal muscle

Narciclasine attenuates diet-induced obesity by promoting oxidative metabolism in skeletal muscle

10.1371/journal.pbio.1002597

Saved in:

Bibliographic Details
Main Authors:	Julien S.G., Kim S.-Y., Brunmeir R., Sinnakannu J.R., Ge X., Li H., Ma W., Yaligar J., Bhanu Prakash K.N., Velan S.S., R�der P.V., Zhang Q., Sim C.K., Wu J., Garcia-Miralles M., Pouladi M.A., Xie W., McFarlane C., Han W., Xu F.
Other Authors:	CANCER SCIENCE INSTITUTE OF SINGAPORE
Format:	Article
Published:	2019
Subjects:	adenine nucleotide translocase cyclic AMP hydroxymethylglutaryl coenzyme A reductase kinase narciclasine reactive oxygen metabolite adenosine diphosphate adenosine triphosphate Amaryllidaceae alkaloid biological marker fatty acid phenanthridine derivative protective agent aerobic metabolism animal cell animal tissue Article blood cell cell metabolism controlled study diet induced obesity drug effect energy expenditure enzyme activation enzyme synthesis fatty acid oxidation glycolysis human human tissue in vitro study lipid metabolism male metabolic clearance mitochondrial membrane potential mitochondrial respiration mouse muscle cell myotube nonhuman physical activity protein blood level signal transduction skeletal muscle adverse effects animal animal experiment C57BL mouse cell culture cell respiration diet drug effects energy metabolism lipid diet metabolism mitochondrion obesity oxidation reduction reaction skeletal muscle cell slow muscle fiber Adenosine Diphosphate Adenosine Triphosphate Amaryllidaceae Alkaloids AMP-Activated Protein Kinases Animals Biomarkers Cell Respiration Cells, Cultured Cyclic AMP Diet Diet, High-Fat Energy Metabolism Enzyme Activation Fatty Acids Humans Male Membrane Potential, Mitochondrial Mice Mice, Inbred C57BL Mitochondria Muscle Fibers, Skeletal Muscle Fibers, Slow-Twitch Muscle, Skeletal Obesity Oxidation-Reduction Phenanthridines Physical Conditioning, Animal Protective Agents Reactive Oxygen Species Signal Transduction
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/161898
Tags:	Add Tag No Tags, Be the first to tag this record!
Institution:	National University of Singapore

Description
Summary:	10.1371/journal.pbio.1002597