The homeobox gene MEIS1 is methylated in BRAFp.V600E mutated colon tumors

• Main Authors: Dihal A.A., Boot A., Van Roon E.H., Schrumpf M., Fariña-Sarasqueta A., Fiocco M., Zeestraten E.C.M., Kuppen P.J.K., Morreau H., Van Wezel T., Boer J.M.
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: 2019
• Subjects: B Raf kinase; glutamic acid; valine; aged; article; BRAF gene; cancer cell; cancer inhibition; cancer patient; cell selection; cohort analysis; colorectal cancer; controlled study; DNA methylation; epithelium cell; exon; female; frozen section; gene expression regulation; gene frequency; gene function; gene mutation; genetic analysis; genetic association; homeobox; human; human cell; human tissue; major clinical study; male; MEIS1 gene; mutational analysis; promoter region; stroma; validation study; Aged; Aspartic Acid; Cell Line, Tumor; Colonic Neoplasms; DNA Methylation; DNA Mutational Analysis; Exons; Female; Gene Expression Regulation, Neoplastic; Homeodomain Proteins; Humans; Male; Middle Aged; Mutation; Neoplasm Proteins; Oligonucleotide Array Sequence Analysis; Promoter Regions, Genetic; Proto-Oncogene Proteins B-raf; Valine
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161457
• Institution: National University of Singapore

10.1371/journal.pone.0079898