Complexation and Sequestration of BMP-2 from an ECM Mimetic Hyaluronan Gel for Improved Bone Formation

• Main Authors: Kisiel M., Klar A.S., Ventura M., Buijs J., Mafina M.-K., Cool S.M., Hilborn J.
• Other Authors: ORTHOPAEDIC SURGERY
• Format: Article
• Published: 2019
• Subjects: alkaline phosphatase; bone morphogenetic protein 2; dermatan sulfate; glycosaminoglycan; heparin; hyaluronic acid; Bmp2 protein, rat; immobilized protein; immunological adjuvant; angiogenesis; animal experiment; animal model; article; assay; binding affinity; binding kinetics; biological activity; bone mass; bone mineral; bone structure; complex formation; controlled study; covalent bond; enzyme activity; extracellular matrix; histology; immunohistochemistry; in vitro study; in vivo study; male; micro-computed tomography; nonhuman; ossification; protein metabolism; protein secretion; protein stability; rat; scanning electron microscopy; surface plasmon resonance; animal; bone development; cell culture; chemistry; drug effects; human; Sprague Dawley rat; time; Adjuvants, Immunologic; Animals; Bone Morphogenetic Protein 2; Cells, Cultured; Humans; Hyaluronic Acid; Immobilized Proteins; Male; Osteogenesis; Rats; Rats, Sprague-Dawley; Time Factors
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161459
• Institution: National University of Singapore

10.1371/journal.pone.0078551