Using an adenosine triphosphate bioluminescent assay to determine effective antibiotic combinations against carbapenem-resistant gram negative bacteria within 24 hours

• Main Authors: Cai Y., Leck H., Lim T.P., Teo J., Lee W., Hsu L.Y., Koh T.H., Tan T.T., Tan T.-Y., Kwa A.L.-H.
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: 2019
• Subjects: adenosine triphosphate; carbapenem; antiinfective agent; carbapenem derivative; Acinetobacter baumannii; antibiotic resistance; Article; bacterial count; bacterial strain; bioluminescence; colony forming unit; concentration (parameters); controlled study; Gram negative bacterium; Klebsiella pneumoniae; measurement accuracy; nonhuman; prospective study; Pseudomonas aeruginosa; receiver operating characteristic; sensitivity and specificity; validation process; dose response; drug effects; luminescence; metabolism; microbial sensitivity test; multidrug resistance; procedures; reproducibility; Adenosine Triphosphate; Anti-Bacterial Agents; Carbapenems; Colony Count, Microbial; Dose-Response Relationship, Drug; Drug Resistance, Multiple, Bacterial; Gram-Negative Bacteria; Luminescent Measurements; Microbial Sensitivity Tests; Reproducibility of Results; ROC Curve
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161485
• Institution: National University of Singapore

10.1371/journal.pone.0140446