An extended polyanion activation surface in insulin degrading enzyme

10.1371/journal.pone.0133114

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Bibliographic Details
Main Authors:	Song E.S., Ozbil M., Zhang T., Sheetz M., Lee D., Tran D., Li S., Prabhakar R., Hersh L.B., Rodgers D.W.
Other Authors:	BIOLOGY (NU)
Format:	Article
Published:	2019
Subjects:	adenosine triphosphate amylin amyloid beta protein anion arginine atrial natriuretic factor glucagon insulin insulinase lysine peptide polyanion deuterium hydrogen polyanions polymer protein binding Article binding site conformational transition controlled study crystallography drug targeting enzyme degradation enzyme structure enzyme substrate insulin metabolism kinetics mathematical analysis molecular docking molecular dynamics mutagenesis mutation polyanion binding surface protein degradation amino acid sequence chemistry conformation genetics metabolism molecular genetics Adenosine Triphosphate Amino Acid Sequence Binding Sites Deuterium Hydrogen Insulysin Molecular Conformation Molecular Docking Simulation Molecular Dynamics Simulation Molecular Sequence Data Mutation Polymers Protein Binding
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/161497
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Institution:	National University of Singapore

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