An extended polyanion activation surface in insulin degrading enzyme

• Main Authors: Song E.S., Ozbil M., Zhang T., Sheetz M., Lee D., Tran D., Li S., Prabhakar R., Hersh L.B., Rodgers D.W.
• Other Authors: BIOLOGY (NU)
• Format: Article
• Published: 2019
• Subjects: adenosine triphosphate; amylin; amyloid beta protein; anion; arginine; atrial natriuretic factor; glucagon; insulin; insulinase; lysine; peptide; polyanion; deuterium; hydrogen; polyanions; polymer; protein binding; Article; binding site; conformational transition; controlled study; crystallography; drug targeting; enzyme degradation; enzyme structure; enzyme substrate; insulin metabolism; kinetics; mathematical analysis; molecular docking; molecular dynamics; mutagenesis; mutation; polyanion binding surface; protein degradation; amino acid sequence; chemistry; conformation; genetics; metabolism; molecular genetics; Adenosine Triphosphate; Amino Acid Sequence; Binding Sites; Deuterium; Hydrogen; Insulysin; Molecular Conformation; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Sequence Data; Mutation; Polymers; Protein Binding
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161497
• Institution: National University of Singapore

10.1371/journal.pone.0133114