An extended polyanion activation surface in insulin degrading enzyme

10.1371/journal.pone.0133114

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Main Authors:	Song E.S., Ozbil M., Zhang T., Sheetz M., Lee D., Tran D., Li S., Prabhakar R., Hersh L.B., Rodgers D.W.
Other Authors:	BIOLOGY (NU)
Format:	Article
Published:	2019
Subjects:	adenosine triphosphate amylin amyloid beta protein anion arginine atrial natriuretic factor glucagon insulin insulinase lysine peptide polyanion deuterium hydrogen polyanions polymer protein binding Article binding site conformational transition controlled study crystallography drug targeting enzyme degradation enzyme structure enzyme substrate insulin metabolism kinetics mathematical analysis molecular docking molecular dynamics mutagenesis mutation polyanion binding surface protein degradation amino acid sequence chemistry conformation genetics metabolism molecular genetics Adenosine Triphosphate Amino Acid Sequence Binding Sites Deuterium Hydrogen Insulysin Molecular Conformation Molecular Docking Simulation Molecular Dynamics Simulation Molecular Sequence Data Mutation Polymers Protein Binding
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/161497
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1614972023-10-31T09:19:00Z An extended polyanion activation surface in insulin degrading enzyme Song E.S. Ozbil M. Zhang T. Sheetz M. Lee D. Tran D. Li S. Prabhakar R. Hersh L.B. Rodgers D.W. BIOLOGY (NU) adenosine triphosphate amylin amyloid beta protein anion arginine atrial natriuretic factor glucagon insulin insulinase lysine peptide polyanion deuterium hydrogen insulinase polyanions polymer protein binding Article binding site conformational transition controlled study crystallography drug targeting enzyme degradation enzyme structure enzyme substrate insulin metabolism kinetics mathematical analysis molecular docking molecular dynamics mutagenesis mutation polyanion binding surface protein degradation amino acid sequence binding site chemistry conformation genetics metabolism molecular genetics Adenosine Triphosphate Amino Acid Sequence Binding Sites Deuterium Hydrogen Insulysin Molecular Conformation Molecular Docking Simulation Molecular Dynamics Simulation Molecular Sequence Data Mutation Polymers Protein Binding 10.1371/journal.pone.0133114 PLoS ONE 10 7 133114 2019-11-06T01:28:28Z 2019-11-06T01:28:28Z 2015 Article Song E.S., Ozbil M., Zhang T., Sheetz M., Lee D., Tran D., Li S., Prabhakar R., Hersh L.B., Rodgers D.W. (2015). An extended polyanion activation surface in insulin degrading enzyme. PLoS ONE 10 (7) : 133114. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0133114 19326203 https://scholarbank.nus.edu.sg/handle/10635/161497 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Unpaywall 20191101
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	adenosine triphosphate amylin amyloid beta protein anion arginine atrial natriuretic factor glucagon insulin insulinase lysine peptide polyanion deuterium hydrogen insulinase polyanions polymer protein binding Article binding site conformational transition controlled study crystallography drug targeting enzyme degradation enzyme structure enzyme substrate insulin metabolism kinetics mathematical analysis molecular docking molecular dynamics mutagenesis mutation polyanion binding surface protein degradation amino acid sequence binding site chemistry conformation genetics metabolism molecular genetics Adenosine Triphosphate Amino Acid Sequence Binding Sites Deuterium Hydrogen Insulysin Molecular Conformation Molecular Docking Simulation Molecular Dynamics Simulation Molecular Sequence Data Mutation Polymers Protein Binding
spellingShingle	adenosine triphosphate amylin amyloid beta protein anion arginine atrial natriuretic factor glucagon insulin insulinase lysine peptide polyanion deuterium hydrogen insulinase polyanions polymer protein binding Article binding site conformational transition controlled study crystallography drug targeting enzyme degradation enzyme structure enzyme substrate insulin metabolism kinetics mathematical analysis molecular docking molecular dynamics mutagenesis mutation polyanion binding surface protein degradation amino acid sequence binding site chemistry conformation genetics metabolism molecular genetics Adenosine Triphosphate Amino Acid Sequence Binding Sites Deuterium Hydrogen Insulysin Molecular Conformation Molecular Docking Simulation Molecular Dynamics Simulation Molecular Sequence Data Mutation Polymers Protein Binding Song E.S. Ozbil M. Zhang T. Sheetz M. Lee D. Tran D. Li S. Prabhakar R. Hersh L.B. Rodgers D.W. An extended polyanion activation surface in insulin degrading enzyme
description	10.1371/journal.pone.0133114
author2	BIOLOGY (NU)
author_facet	BIOLOGY (NU) Song E.S. Ozbil M. Zhang T. Sheetz M. Lee D. Tran D. Li S. Prabhakar R. Hersh L.B. Rodgers D.W.
format	Article
author	Song E.S. Ozbil M. Zhang T. Sheetz M. Lee D. Tran D. Li S. Prabhakar R. Hersh L.B. Rodgers D.W.
author_sort	Song E.S.
title	An extended polyanion activation surface in insulin degrading enzyme
title_short	An extended polyanion activation surface in insulin degrading enzyme
title_full	An extended polyanion activation surface in insulin degrading enzyme
title_fullStr	An extended polyanion activation surface in insulin degrading enzyme
title_full_unstemmed	An extended polyanion activation surface in insulin degrading enzyme
title_sort	extended polyanion activation surface in insulin degrading enzyme
publishDate	2019
url	https://scholarbank.nus.edu.sg/handle/10635/161497
_version_	1781791774916739072

An extended polyanion activation surface in insulin degrading enzyme

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