Melatonin suppresses toll like receptor 4-dependent caspase-3 signaling activation coupled with reduced production of proinflammatory mediators in Hypoxic Microgli?

• Main Authors: Yao L., Lu P., Ling E.-A.
• Other Authors: ANATOMY
• Format: Article
• Published: 2019
• Subjects: caspase 3; inducible nitric oxide synthase; interleukin 1beta; melatonin; messenger RNA; toll like receptor 4; transcription factor RelA; tumor necrosis factor; autacoid; animal cell; animal experiment; animal model; animal tissue; antiinflammatory activity; Article; brain hypoxia; cell hypoxia; controlled study; in vitro study; microglia; newborn; newborn hypoxia; nonhuman; protein expression; rat; animal; cytology; deficiency; drug effects; enzyme activation; gene expression regulation; gene silencing; genetics; metabolism; signal transduction; Wistar rat; Animals; Caspase 3; Cell Hypoxia; Enzyme Activation; Gene Expression Regulation; Gene Knockdown Techniques; Inflammation Mediators; Melatonin; Microglia; Rats; Rats, Wistar; Signal Transduction; Toll-Like Receptor 4
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161546
• Institution: National University of Singapore

10.1371/journal.pone.0166010