Melatonin suppresses toll like receptor 4-dependent caspase-3 signaling activation coupled with reduced production of proinflammatory mediators in Hypoxic Microgli?

Melatonin suppresses toll like receptor 4-dependent caspase-3 signaling activation coupled with reduced production of proinflammatory mediators in Hypoxic Microgli?

10.1371/journal.pone.0166010

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Bibliographic Details
Main Authors:	Yao L., Lu P., Ling E.-A.
Other Authors:	ANATOMY
Format:	Article
Published:	2019
Subjects:	caspase 3 inducible nitric oxide synthase interleukin 1beta melatonin messenger RNA toll like receptor 4 transcription factor RelA tumor necrosis factor autacoid animal cell animal experiment animal model animal tissue antiinflammatory activity Article brain hypoxia cell hypoxia controlled study in vitro study microglia newborn newborn hypoxia nonhuman protein expression rat animal cytology deficiency drug effects enzyme activation gene expression regulation gene silencing genetics metabolism signal transduction Wistar rat Animals Caspase 3 Cell Hypoxia Enzyme Activation Gene Expression Regulation Gene Knockdown Techniques Inflammation Mediators Melatonin Microglia Rats Rats, Wistar Signal Transduction Toll-Like Receptor 4
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/161546
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Institution:	National University of Singapore

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