A P-loop mutation in G? subunits prevents transition to the active state: Implications for G-protein signaling in fungal pathogenesis

A P-loop mutation in G? subunits prevents transition to the active state: Implications for G-protein signaling in fungal pathogenesis

10.1371/journal.ppat.1002553

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Bibliographic Details
Main Authors:	Bosch D.E., Willard F.S., Ramanujam R., Kimple A.J., Willard M.D., Naqvi N.I., Siderovski D.P.
Other Authors:	BIOLOGICAL SCIENCES
Format:	Article
Published:	2019
Subjects:	aluminum derivative aluminum tetrafluoride arginine G protein coupled receptor guanine nucleotide binding protein guanosine triphosphatase kb 1753 unclassified drug guanine nucleotide binding protein alpha subunit mutant protein article binding affinity binding site controlled study crystal structure DNA binding motif fungal strain fungus gene locus gene mutation hydrolysis intracellular signaling nonhuman pathogenesis protein conformation protein protein interaction signal transduction amino acid substitution chemical structure chemistry enzyme active site genetics Hordeum Magnaporthe metabolism microbiology mycosis pathogenicity physiology plant disease plant leaf point mutation protein folding protein tertiary structure X ray crystallography Fungi Magnaporthe grisea Magnaporthe oryzae Thespesia grandiflora Amino Acid Substitution Catalytic Domain Crystallography, X-Ray GTP-Binding Protein alpha Subunits Models, Molecular Mutant Proteins Mycoses Plant Diseases Plant Leaves Point Mutation Protein Folding Protein Structure, Tertiary Signal Transduction
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/161643
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Institution:	National University of Singapore

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Summary:	10.1371/journal.ppat.1002553