A P-loop mutation in G? subunits prevents transition to the active state: Implications for G-protein signaling in fungal pathogenesis

• Main Authors: Bosch D.E., Willard F.S., Ramanujam R., Kimple A.J., Willard M.D., Naqvi N.I., Siderovski D.P.
• Other Authors: BIOLOGICAL SCIENCES
• Format: Article
• Published: 2019
• Subjects: aluminum derivative; aluminum tetrafluoride; arginine; G protein coupled receptor; guanine nucleotide binding protein; guanosine triphosphatase; kb 1753; unclassified drug; guanine nucleotide binding protein alpha subunit; mutant protein; article; binding affinity; binding site; controlled study; crystal structure; DNA binding motif; fungal strain; fungus; gene locus; gene mutation; hydrolysis; intracellular signaling; nonhuman; pathogenesis; protein conformation; protein protein interaction; signal transduction; amino acid substitution; chemical structure; chemistry; enzyme active site; genetics; Hordeum; Magnaporthe; metabolism; microbiology; mycosis; pathogenicity; physiology; plant disease; plant leaf; point mutation; protein folding; protein tertiary structure; X ray crystallography; Fungi; Magnaporthe grisea; Magnaporthe oryzae; Thespesia grandiflora; Amino Acid Substitution; Catalytic Domain; Crystallography, X-Ray; GTP-Binding Protein alpha Subunits; Models, Molecular; Mutant Proteins; Mycoses; Plant Diseases; Plant Leaves; Point Mutation; Protein Folding; Protein Structure, Tertiary; Signal Transduction
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161643
• Institution: National University of Singapore

10.1371/journal.ppat.1002553