A P-loop mutation in G? subunits prevents transition to the active state: Implications for G-protein signaling in fungal pathogenesis

10.1371/journal.ppat.1002553

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Main Authors:	Bosch D.E., Willard F.S., Ramanujam R., Kimple A.J., Willard M.D., Naqvi N.I., Siderovski D.P.
Other Authors:	BIOLOGICAL SCIENCES
Format:	Article
Published:	2019
Subjects:	aluminum derivative aluminum tetrafluoride arginine G protein coupled receptor guanine nucleotide binding protein guanosine triphosphatase kb 1753 unclassified drug guanine nucleotide binding protein alpha subunit mutant protein article binding affinity binding site controlled study crystal structure DNA binding motif fungal strain fungus gene locus gene mutation hydrolysis intracellular signaling nonhuman pathogenesis protein conformation protein protein interaction signal transduction amino acid substitution chemical structure chemistry enzyme active site genetics Hordeum Magnaporthe metabolism microbiology mycosis pathogenicity physiology plant disease plant leaf point mutation protein folding protein tertiary structure X ray crystallography Fungi Magnaporthe grisea Magnaporthe oryzae Thespesia grandiflora Amino Acid Substitution Catalytic Domain Crystallography, X-Ray GTP-Binding Protein alpha Subunits Models, Molecular Mutant Proteins Mycoses Plant Diseases Plant Leaves Point Mutation Protein Folding Protein Structure, Tertiary Signal Transduction
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/161643
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1616432024-04-03T10:36:00Z A P-loop mutation in G? subunits prevents transition to the active state: Implications for G-protein signaling in fungal pathogenesis Bosch D.E. Willard F.S. Ramanujam R. Kimple A.J. Willard M.D. Naqvi N.I. Siderovski D.P. BIOLOGICAL SCIENCES aluminum derivative aluminum tetrafluoride arginine G protein coupled receptor guanine nucleotide binding protein guanosine triphosphatase kb 1753 unclassified drug guanine nucleotide binding protein alpha subunit mutant protein article binding affinity binding site controlled study crystal structure DNA binding motif fungal strain fungus gene locus gene mutation hydrolysis intracellular signaling nonhuman pathogenesis protein conformation protein protein interaction signal transduction amino acid substitution chemical structure chemistry enzyme active site genetics Hordeum Magnaporthe metabolism microbiology mycosis pathogenicity physiology plant disease plant leaf point mutation protein folding protein tertiary structure signal transduction X ray crystallography Fungi Magnaporthe grisea Magnaporthe oryzae Thespesia grandiflora Amino Acid Substitution Catalytic Domain Crystallography, X-Ray GTP-Binding Protein alpha Subunits Hordeum Magnaporthe Models, Molecular Mutant Proteins Mycoses Plant Diseases Plant Leaves Point Mutation Protein Folding Protein Structure, Tertiary Signal Transduction 10.1371/journal.ppat.1002553 PLoS Pathogens 8 2 e1002553 2019-11-06T09:30:26Z 2019-11-06T09:30:26Z 2012 Article Bosch D.E., Willard F.S., Ramanujam R., Kimple A.J., Willard M.D., Naqvi N.I., Siderovski D.P. (2012). A P-loop mutation in G? subunits prevents transition to the active state: Implications for G-protein signaling in fungal pathogenesis. PLoS Pathogens 8 (2) : e1002553. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.ppat.1002553 15537366 https://scholarbank.nus.edu.sg/handle/10635/161643 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Unpaywall 20191101
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	aluminum derivative aluminum tetrafluoride arginine G protein coupled receptor guanine nucleotide binding protein guanosine triphosphatase kb 1753 unclassified drug guanine nucleotide binding protein alpha subunit mutant protein article binding affinity binding site controlled study crystal structure DNA binding motif fungal strain fungus gene locus gene mutation hydrolysis intracellular signaling nonhuman pathogenesis protein conformation protein protein interaction signal transduction amino acid substitution chemical structure chemistry enzyme active site genetics Hordeum Magnaporthe metabolism microbiology mycosis pathogenicity physiology plant disease plant leaf point mutation protein folding protein tertiary structure signal transduction X ray crystallography Fungi Magnaporthe grisea Magnaporthe oryzae Thespesia grandiflora Amino Acid Substitution Catalytic Domain Crystallography, X-Ray GTP-Binding Protein alpha Subunits Hordeum Magnaporthe Models, Molecular Mutant Proteins Mycoses Plant Diseases Plant Leaves Point Mutation Protein Folding Protein Structure, Tertiary Signal Transduction
spellingShingle	aluminum derivative aluminum tetrafluoride arginine G protein coupled receptor guanine nucleotide binding protein guanosine triphosphatase kb 1753 unclassified drug guanine nucleotide binding protein alpha subunit mutant protein article binding affinity binding site controlled study crystal structure DNA binding motif fungal strain fungus gene locus gene mutation hydrolysis intracellular signaling nonhuman pathogenesis protein conformation protein protein interaction signal transduction amino acid substitution chemical structure chemistry enzyme active site genetics Hordeum Magnaporthe metabolism microbiology mycosis pathogenicity physiology plant disease plant leaf point mutation protein folding protein tertiary structure signal transduction X ray crystallography Fungi Magnaporthe grisea Magnaporthe oryzae Thespesia grandiflora Amino Acid Substitution Catalytic Domain Crystallography, X-Ray GTP-Binding Protein alpha Subunits Hordeum Magnaporthe Models, Molecular Mutant Proteins Mycoses Plant Diseases Plant Leaves Point Mutation Protein Folding Protein Structure, Tertiary Signal Transduction Bosch D.E. Willard F.S. Ramanujam R. Kimple A.J. Willard M.D. Naqvi N.I. Siderovski D.P. A P-loop mutation in G? subunits prevents transition to the active state: Implications for G-protein signaling in fungal pathogenesis
description	10.1371/journal.ppat.1002553
author2	BIOLOGICAL SCIENCES
author_facet	BIOLOGICAL SCIENCES Bosch D.E. Willard F.S. Ramanujam R. Kimple A.J. Willard M.D. Naqvi N.I. Siderovski D.P.
format	Article
author	Bosch D.E. Willard F.S. Ramanujam R. Kimple A.J. Willard M.D. Naqvi N.I. Siderovski D.P.
author_sort	Bosch D.E.
title	A P-loop mutation in G? subunits prevents transition to the active state: Implications for G-protein signaling in fungal pathogenesis
title_short	A P-loop mutation in G? subunits prevents transition to the active state: Implications for G-protein signaling in fungal pathogenesis
title_full	A P-loop mutation in G? subunits prevents transition to the active state: Implications for G-protein signaling in fungal pathogenesis
title_fullStr	A P-loop mutation in G? subunits prevents transition to the active state: Implications for G-protein signaling in fungal pathogenesis
title_full_unstemmed	A P-loop mutation in G? subunits prevents transition to the active state: Implications for G-protein signaling in fungal pathogenesis
title_sort	p-loop mutation in g? subunits prevents transition to the active state: implications for g-protein signaling in fungal pathogenesis
publishDate	2019
url	https://scholarbank.nus.edu.sg/handle/10635/161643
_version_	1795374109505355776

A P-loop mutation in G? subunits prevents transition to the active state: Implications for G-protein signaling in fungal pathogenesis

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