Evaluation of chikungunya diagnostic assays: Differences in sensitivity of serology assays in two independent outbreaks

• Main Authors: Yap G., Pok K.-Y., Lai Y.-L., Hapuarachchi H.-C., Chow A., Leo Y.-S., Tan L.-K., Ng L.-C.
• Other Authors: SAW SWEE HOCK SCHOOL OF PUBLIC HEALTH
• Format: Article
• Published: 2019
• Subjects: immunoglobulin M; diagnostic agent; virus antibody; virus antigen; virus envelope protein; virus RNA; antigen detection; article; chikungunya; Chikungunya alphavirus; clinical article; controlled study; enzyme linked immunosorbent assay; human; intermethod comparison; molecular probe; nonhuman; real time polymerase chain reaction; reverse transcription polymerase chain reaction; sensitivity analysis; sensitivity and specificity; serology; Alphavirus infection; amino acid substitution; blood; comparative study; epidemic; evaluation; genetics; immunoassay; immunology; methodology; point mutation; polymerase chain reaction; Singapore; virology; Alphavirus Infections; Amino Acid Substitution; Antibodies, Viral; Antigens, Viral; Chikungunya virus; Disease Outbreaks; Humans; Immunoassay; Immunoglobulin M; Point Mutation; Polymerase Chain Reaction; RNA, Viral; Sensitivity and Specificity; Viral Envelope Proteins; Virology
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161660
• Institution: National University of Singapore

10.1371/journal.pntd.0000753