Molecular integrative clustering of asian gastric cell lines revealed two distinct chemosensitivity clusters

• Main Authors: Choong M.L., Tan S.H., Tan T.Z., Manesh S., Ngo A., Yong J.W.Y., Yang H.H., Lee M.A.
• Other Authors: CANCER SCIENCE INSTITUTE OF SINGAPORE
• Format: Article
• Published: 2019
• Subjects: 2 (2 difluoromethylbenzimidazol 1 yl) 4,6 dimorpholino 1,3,5 triazine; 2 (4 hydroxyphenyl) 4 morpholinopyrido[3',2':4,5]furo[3,2 d]pyrimidine; 7,8 dihydro 2 [4 (trifluoromethyl)phenyl] 5h thiopyrano[4,3 d]pyrimidin 4 ol; antineoplastic agent; benzyloxycarbonylleucylleucylleucinal; bortezomib; dactolisib; dasatinib; dovitinib; enzyme inhibitor; fluorouracil; gsk 269962a; luminespib; midostaurin; n (2,3 dihydroxypropoxy) 3,4 difluoro 2 (2 fluoro 4 iodoanilino)benzamide; panobinostat; phosphatidylinositol 3 kinase inhibitor; pik 75; proteosome inhibitor; tanespimycin; unclassified drug; protein kinase; Article; Asian; cancer chemotherapy; cancer survival; chemosensitivity; comparative genomic hybridization; controlled study; copy number variation; drug response; gastric cancer cell line; gene dosage; gene expression; gene mutation; genomics; heterozygosity loss; human; human cell; intracellular signaling; mitochondrion; oxidative phosphorylation; stomach cancer; transcription regulation; Asian continental ancestry group; cluster analysis; drug effects; genetics; IC50; mutation; pathology; signal transduction; stomach tumor; tumor cell line; Antineoplastic Agents; Asian Continental Ancestry Group; Cell Line, Tumor; Cluster Analysis; Humans; Inhibitory Concentration 50; Mutation; Protein Kinases; Signal Transduction; Stomach Neoplasms
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161762
• Institution: National University of Singapore

10.1371/journal.pone.0111146