Molecular integrative clustering of asian gastric cell lines revealed two distinct chemosensitivity clusters
10.1371/journal.pone.0111146
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sg-nus-scholar.10635-1617622023-10-31T20:30:04Z Molecular integrative clustering of asian gastric cell lines revealed two distinct chemosensitivity clusters Choong M.L. Tan S.H. Tan T.Z. Manesh S. Ngo A. Yong J.W.Y. Yang H.H. Lee M.A. CANCER SCIENCE INSTITUTE OF SINGAPORE 2 (2 difluoromethylbenzimidazol 1 yl) 4,6 dimorpholino 1,3,5 triazine 2 (4 hydroxyphenyl) 4 morpholinopyrido[3',2':4,5]furo[3,2 d]pyrimidine 7,8 dihydro 2 [4 (trifluoromethyl)phenyl] 5h thiopyrano[4,3 d]pyrimidin 4 ol antineoplastic agent benzyloxycarbonylleucylleucylleucinal bortezomib dactolisib dasatinib dovitinib enzyme inhibitor fluorouracil gsk 269962a luminespib midostaurin n (2,3 dihydroxypropoxy) 3,4 difluoro 2 (2 fluoro 4 iodoanilino)benzamide panobinostat phosphatidylinositol 3 kinase inhibitor pik 75 proteosome inhibitor tanespimycin unclassified drug protein kinase Article Asian cancer chemotherapy cancer survival chemosensitivity comparative genomic hybridization controlled study copy number variation drug response gastric cancer cell line gene dosage gene expression gene mutation genomics heterozygosity loss human human cell intracellular signaling mitochondrion oxidative phosphorylation stomach cancer transcription regulation Asian continental ancestry group cluster analysis drug effects genetics IC50 mutation pathology signal transduction stomach tumor tumor cell line Antineoplastic Agents Asian Continental Ancestry Group Cell Line, Tumor Cluster Analysis Humans Inhibitory Concentration 50 Mutation Protein Kinases Signal Transduction Stomach Neoplasms 10.1371/journal.pone.0111146 PLoS ONE 9 10 e111146 2019-11-07T05:05:35Z 2019-11-07T05:05:35Z 2014 Article Choong M.L., Tan S.H., Tan T.Z., Manesh S., Ngo A., Yong J.W.Y., Yang H.H., Lee M.A. (2014). Molecular integrative clustering of asian gastric cell lines revealed two distinct chemosensitivity clusters. PLoS ONE 9 (10) : e111146. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0111146 19326203 https://scholarbank.nus.edu.sg/handle/10635/161762 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Unpaywall 20191101 |
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2 (2 difluoromethylbenzimidazol 1 yl) 4,6 dimorpholino 1,3,5 triazine 2 (4 hydroxyphenyl) 4 morpholinopyrido[3',2':4,5]furo[3,2 d]pyrimidine 7,8 dihydro 2 [4 (trifluoromethyl)phenyl] 5h thiopyrano[4,3 d]pyrimidin 4 ol antineoplastic agent benzyloxycarbonylleucylleucylleucinal bortezomib dactolisib dasatinib dovitinib enzyme inhibitor fluorouracil gsk 269962a luminespib midostaurin n (2,3 dihydroxypropoxy) 3,4 difluoro 2 (2 fluoro 4 iodoanilino)benzamide panobinostat phosphatidylinositol 3 kinase inhibitor pik 75 proteosome inhibitor tanespimycin unclassified drug protein kinase Article Asian cancer chemotherapy cancer survival chemosensitivity comparative genomic hybridization controlled study copy number variation drug response gastric cancer cell line gene dosage gene expression gene mutation genomics heterozygosity loss human human cell intracellular signaling mitochondrion oxidative phosphorylation stomach cancer transcription regulation Asian continental ancestry group cluster analysis drug effects genetics IC50 mutation pathology signal transduction stomach tumor tumor cell line Antineoplastic Agents Asian Continental Ancestry Group Cell Line, Tumor Cluster Analysis Humans Inhibitory Concentration 50 Mutation Protein Kinases Signal Transduction Stomach Neoplasms |
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2 (2 difluoromethylbenzimidazol 1 yl) 4,6 dimorpholino 1,3,5 triazine 2 (4 hydroxyphenyl) 4 morpholinopyrido[3',2':4,5]furo[3,2 d]pyrimidine 7,8 dihydro 2 [4 (trifluoromethyl)phenyl] 5h thiopyrano[4,3 d]pyrimidin 4 ol antineoplastic agent benzyloxycarbonylleucylleucylleucinal bortezomib dactolisib dasatinib dovitinib enzyme inhibitor fluorouracil gsk 269962a luminespib midostaurin n (2,3 dihydroxypropoxy) 3,4 difluoro 2 (2 fluoro 4 iodoanilino)benzamide panobinostat phosphatidylinositol 3 kinase inhibitor pik 75 proteosome inhibitor tanespimycin unclassified drug protein kinase Article Asian cancer chemotherapy cancer survival chemosensitivity comparative genomic hybridization controlled study copy number variation drug response gastric cancer cell line gene dosage gene expression gene mutation genomics heterozygosity loss human human cell intracellular signaling mitochondrion oxidative phosphorylation stomach cancer transcription regulation Asian continental ancestry group cluster analysis drug effects genetics IC50 mutation pathology signal transduction stomach tumor tumor cell line Antineoplastic Agents Asian Continental Ancestry Group Cell Line, Tumor Cluster Analysis Humans Inhibitory Concentration 50 Mutation Protein Kinases Signal Transduction Stomach Neoplasms Choong M.L. Tan S.H. Tan T.Z. Manesh S. Ngo A. Yong J.W.Y. Yang H.H. Lee M.A. Molecular integrative clustering of asian gastric cell lines revealed two distinct chemosensitivity clusters |
description |
10.1371/journal.pone.0111146 |
author2 |
CANCER SCIENCE INSTITUTE OF SINGAPORE |
author_facet |
CANCER SCIENCE INSTITUTE OF SINGAPORE Choong M.L. Tan S.H. Tan T.Z. Manesh S. Ngo A. Yong J.W.Y. Yang H.H. Lee M.A. |
format |
Article |
author |
Choong M.L. Tan S.H. Tan T.Z. Manesh S. Ngo A. Yong J.W.Y. Yang H.H. Lee M.A. |
author_sort |
Choong M.L. |
title |
Molecular integrative clustering of asian gastric cell lines revealed two distinct chemosensitivity clusters |
title_short |
Molecular integrative clustering of asian gastric cell lines revealed two distinct chemosensitivity clusters |
title_full |
Molecular integrative clustering of asian gastric cell lines revealed two distinct chemosensitivity clusters |
title_fullStr |
Molecular integrative clustering of asian gastric cell lines revealed two distinct chemosensitivity clusters |
title_full_unstemmed |
Molecular integrative clustering of asian gastric cell lines revealed two distinct chemosensitivity clusters |
title_sort |
molecular integrative clustering of asian gastric cell lines revealed two distinct chemosensitivity clusters |
publishDate |
2019 |
url |
https://scholarbank.nus.edu.sg/handle/10635/161762 |
_version_ |
1781791831485317120 |