Molecular integrative clustering of asian gastric cell lines revealed two distinct chemosensitivity clusters

10.1371/journal.pone.0111146

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Main Authors: Choong M.L., Tan S.H., Tan T.Z., Manesh S., Ngo A., Yong J.W.Y., Yang H.H., Lee M.A.
Other Authors: CANCER SCIENCE INSTITUTE OF SINGAPORE
Format: Article
Published: 2019
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Online Access:https://scholarbank.nus.edu.sg/handle/10635/161762
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spelling sg-nus-scholar.10635-1617622023-10-31T20:30:04Z Molecular integrative clustering of asian gastric cell lines revealed two distinct chemosensitivity clusters Choong M.L. Tan S.H. Tan T.Z. Manesh S. Ngo A. Yong J.W.Y. Yang H.H. Lee M.A. CANCER SCIENCE INSTITUTE OF SINGAPORE 2 (2 difluoromethylbenzimidazol 1 yl) 4,6 dimorpholino 1,3,5 triazine 2 (4 hydroxyphenyl) 4 morpholinopyrido[3',2':4,5]furo[3,2 d]pyrimidine 7,8 dihydro 2 [4 (trifluoromethyl)phenyl] 5h thiopyrano[4,3 d]pyrimidin 4 ol antineoplastic agent benzyloxycarbonylleucylleucylleucinal bortezomib dactolisib dasatinib dovitinib enzyme inhibitor fluorouracil gsk 269962a luminespib midostaurin n (2,3 dihydroxypropoxy) 3,4 difluoro 2 (2 fluoro 4 iodoanilino)benzamide panobinostat phosphatidylinositol 3 kinase inhibitor pik 75 proteosome inhibitor tanespimycin unclassified drug protein kinase Article Asian cancer chemotherapy cancer survival chemosensitivity comparative genomic hybridization controlled study copy number variation drug response gastric cancer cell line gene dosage gene expression gene mutation genomics heterozygosity loss human human cell intracellular signaling mitochondrion oxidative phosphorylation stomach cancer transcription regulation Asian continental ancestry group cluster analysis drug effects genetics IC50 mutation pathology signal transduction stomach tumor tumor cell line Antineoplastic Agents Asian Continental Ancestry Group Cell Line, Tumor Cluster Analysis Humans Inhibitory Concentration 50 Mutation Protein Kinases Signal Transduction Stomach Neoplasms 10.1371/journal.pone.0111146 PLoS ONE 9 10 e111146 2019-11-07T05:05:35Z 2019-11-07T05:05:35Z 2014 Article Choong M.L., Tan S.H., Tan T.Z., Manesh S., Ngo A., Yong J.W.Y., Yang H.H., Lee M.A. (2014). Molecular integrative clustering of asian gastric cell lines revealed two distinct chemosensitivity clusters. PLoS ONE 9 (10) : e111146. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0111146 19326203 https://scholarbank.nus.edu.sg/handle/10635/161762 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Unpaywall 20191101
institution National University of Singapore
building NUS Library
continent Asia
country Singapore
Singapore
content_provider NUS Library
collection ScholarBank@NUS
topic 2 (2 difluoromethylbenzimidazol 1 yl) 4,6 dimorpholino 1,3,5 triazine
2 (4 hydroxyphenyl) 4 morpholinopyrido[3',2':4,5]furo[3,2 d]pyrimidine
7,8 dihydro 2 [4 (trifluoromethyl)phenyl] 5h thiopyrano[4,3 d]pyrimidin 4 ol
antineoplastic agent
benzyloxycarbonylleucylleucylleucinal
bortezomib
dactolisib
dasatinib
dovitinib
enzyme inhibitor
fluorouracil
gsk 269962a
luminespib
midostaurin
n (2,3 dihydroxypropoxy) 3,4 difluoro 2 (2 fluoro 4 iodoanilino)benzamide
panobinostat
phosphatidylinositol 3 kinase inhibitor
pik 75
proteosome inhibitor
tanespimycin
unclassified drug
protein kinase
Article
Asian
cancer chemotherapy
cancer survival
chemosensitivity
comparative genomic hybridization
controlled study
copy number variation
drug response
gastric cancer cell line
gene dosage
gene expression
gene mutation
genomics
heterozygosity loss
human
human cell
intracellular signaling
mitochondrion
oxidative phosphorylation
stomach cancer
transcription regulation
Asian continental ancestry group
cluster analysis
drug effects
genetics
IC50
mutation
pathology
signal transduction
stomach tumor
tumor cell line
Antineoplastic Agents
Asian Continental Ancestry Group
Cell Line, Tumor
Cluster Analysis
Humans
Inhibitory Concentration 50
Mutation
Protein Kinases
Signal Transduction
Stomach Neoplasms
spellingShingle 2 (2 difluoromethylbenzimidazol 1 yl) 4,6 dimorpholino 1,3,5 triazine
2 (4 hydroxyphenyl) 4 morpholinopyrido[3',2':4,5]furo[3,2 d]pyrimidine
7,8 dihydro 2 [4 (trifluoromethyl)phenyl] 5h thiopyrano[4,3 d]pyrimidin 4 ol
antineoplastic agent
benzyloxycarbonylleucylleucylleucinal
bortezomib
dactolisib
dasatinib
dovitinib
enzyme inhibitor
fluorouracil
gsk 269962a
luminespib
midostaurin
n (2,3 dihydroxypropoxy) 3,4 difluoro 2 (2 fluoro 4 iodoanilino)benzamide
panobinostat
phosphatidylinositol 3 kinase inhibitor
pik 75
proteosome inhibitor
tanespimycin
unclassified drug
protein kinase
Article
Asian
cancer chemotherapy
cancer survival
chemosensitivity
comparative genomic hybridization
controlled study
copy number variation
drug response
gastric cancer cell line
gene dosage
gene expression
gene mutation
genomics
heterozygosity loss
human
human cell
intracellular signaling
mitochondrion
oxidative phosphorylation
stomach cancer
transcription regulation
Asian continental ancestry group
cluster analysis
drug effects
genetics
IC50
mutation
pathology
signal transduction
stomach tumor
tumor cell line
Antineoplastic Agents
Asian Continental Ancestry Group
Cell Line, Tumor
Cluster Analysis
Humans
Inhibitory Concentration 50
Mutation
Protein Kinases
Signal Transduction
Stomach Neoplasms
Choong M.L.
Tan S.H.
Tan T.Z.
Manesh S.
Ngo A.
Yong J.W.Y.
Yang H.H.
Lee M.A.
Molecular integrative clustering of asian gastric cell lines revealed two distinct chemosensitivity clusters
description 10.1371/journal.pone.0111146
author2 CANCER SCIENCE INSTITUTE OF SINGAPORE
author_facet CANCER SCIENCE INSTITUTE OF SINGAPORE
Choong M.L.
Tan S.H.
Tan T.Z.
Manesh S.
Ngo A.
Yong J.W.Y.
Yang H.H.
Lee M.A.
format Article
author Choong M.L.
Tan S.H.
Tan T.Z.
Manesh S.
Ngo A.
Yong J.W.Y.
Yang H.H.
Lee M.A.
author_sort Choong M.L.
title Molecular integrative clustering of asian gastric cell lines revealed two distinct chemosensitivity clusters
title_short Molecular integrative clustering of asian gastric cell lines revealed two distinct chemosensitivity clusters
title_full Molecular integrative clustering of asian gastric cell lines revealed two distinct chemosensitivity clusters
title_fullStr Molecular integrative clustering of asian gastric cell lines revealed two distinct chemosensitivity clusters
title_full_unstemmed Molecular integrative clustering of asian gastric cell lines revealed two distinct chemosensitivity clusters
title_sort molecular integrative clustering of asian gastric cell lines revealed two distinct chemosensitivity clusters
publishDate 2019
url https://scholarbank.nus.edu.sg/handle/10635/161762
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