Toxoplasma gondii is dependent on glutamine and alters migratory profile of infected host bone marrow derived immune cells through SNAT2 and CXCR4 pathways

10.1371/journal.pone.0109803

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Main Authors:	Lee I.-P., Evans A.K., Yang C., Works M.G., Kumar V., De Miguel Z., Manley N.C., Sapolsky R.M.
Other Authors:	DEPT OF PHARMACOLOGY
Format:	Article
Published:	2019
Subjects:	amino acid transporter B7 antigen chemokine receptor CXCR4 glutamine lipopolysaccharide phosphatidylinositol 3 kinase Rho kinase sodium dependent neutral amino acid transporter 2 stromal cell derived factor 1alpha unclassified drug CXCL12 protein, rat Cxcr4 protein, rat luciferase SNAT2 protein, rat stromal cell derived factor 1 amino acid transport animal cell animal tissue Article bone marrow cell damage cell migration cell motility controlled study dendritic cell female host cell immunocompetent cell in vitro study intracellular signaling nonhuman parasite cultivation parasite viability phenotype protein expression protein protein interaction rat Toxoplasma gondii toxoplasmosis Western blotting animal bone marrow cell cell differentiation cell motion drug effects fibroblast gene expression regulation genetics host pathogen interaction human immunology metabolism newborn parasitology pathology primary cell culture reporter gene signal transduction Sprague Dawley rat Toxoplasma transgenic organism Amino Acid Transport Systems Animals Animals, Newborn Bone Marrow Cells Cell Differentiation Cell Movement Chemokine CXCL12 Dendritic Cells Fibroblasts Gene Expression Regulation Genes, Reporter Glutamine Host-Pathogen Interactions Humans Lipopolysaccharides Luciferases Organisms, Genetically Modified Primary Cell Culture Rats Rats, Sprague-Dawley Receptors, CXCR4 Signal Transduction
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/161770
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1617702023-10-31T08:16:36Z Toxoplasma gondii is dependent on glutamine and alters migratory profile of infected host bone marrow derived immune cells through SNAT2 and CXCR4 pathways Lee I.-P. Evans A.K. Yang C. Works M.G. Kumar V. De Miguel Z. Manley N.C. Sapolsky R.M. DEPT OF PHARMACOLOGY amino acid transporter B7 antigen chemokine receptor CXCR4 glutamine lipopolysaccharide phosphatidylinositol 3 kinase Rho kinase sodium dependent neutral amino acid transporter 2 stromal cell derived factor 1alpha unclassified drug amino acid transporter chemokine receptor CXCR4 CXCL12 protein, rat Cxcr4 protein, rat glutamine lipopolysaccharide luciferase SNAT2 protein, rat stromal cell derived factor 1 amino acid transport animal cell animal tissue Article bone marrow cell damage cell migration cell motility controlled study dendritic cell female host cell immunocompetent cell in vitro study intracellular signaling nonhuman parasite cultivation parasite viability phenotype protein expression protein protein interaction rat Toxoplasma gondii toxoplasmosis Western blotting animal bone marrow cell cell differentiation cell motion drug effects fibroblast gene expression regulation genetics host pathogen interaction human immunology metabolism newborn parasitology pathology primary cell culture reporter gene signal transduction Sprague Dawley rat Toxoplasma transgenic organism Toxoplasma gondii Amino Acid Transport Systems Animals Animals, Newborn Bone Marrow Cells Cell Differentiation Cell Movement Chemokine CXCL12 Dendritic Cells Fibroblasts Gene Expression Regulation Genes, Reporter Glutamine Host-Pathogen Interactions Humans Lipopolysaccharides Luciferases Organisms, Genetically Modified Primary Cell Culture Rats Rats, Sprague-Dawley Receptors, CXCR4 Signal Transduction Toxoplasma 10.1371/journal.pone.0109803 PLoS ONE 9 10 e109803 2019-11-07T05:07:01Z 2019-11-07T05:07:01Z 2014 Article Lee I.-P., Evans A.K., Yang C., Works M.G., Kumar V., De Miguel Z., Manley N.C., Sapolsky R.M. (2014). Toxoplasma gondii is dependent on glutamine and alters migratory profile of infected host bone marrow derived immune cells through SNAT2 and CXCR4 pathways. PLoS ONE 9 (10) : e109803. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0109803 19326203 https://scholarbank.nus.edu.sg/handle/10635/161770 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Unpaywall 20191101
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	amino acid transporter B7 antigen chemokine receptor CXCR4 glutamine lipopolysaccharide phosphatidylinositol 3 kinase Rho kinase sodium dependent neutral amino acid transporter 2 stromal cell derived factor 1alpha unclassified drug amino acid transporter chemokine receptor CXCR4 CXCL12 protein, rat Cxcr4 protein, rat glutamine lipopolysaccharide luciferase SNAT2 protein, rat stromal cell derived factor 1 amino acid transport animal cell animal tissue Article bone marrow cell damage cell migration cell motility controlled study dendritic cell female host cell immunocompetent cell in vitro study intracellular signaling nonhuman parasite cultivation parasite viability phenotype protein expression protein protein interaction rat Toxoplasma gondii toxoplasmosis Western blotting animal bone marrow cell cell differentiation cell motion drug effects fibroblast gene expression regulation genetics host pathogen interaction human immunology metabolism newborn parasitology pathology primary cell culture reporter gene signal transduction Sprague Dawley rat Toxoplasma transgenic organism Toxoplasma gondii Amino Acid Transport Systems Animals Animals, Newborn Bone Marrow Cells Cell Differentiation Cell Movement Chemokine CXCL12 Dendritic Cells Fibroblasts Gene Expression Regulation Genes, Reporter Glutamine Host-Pathogen Interactions Humans Lipopolysaccharides Luciferases Organisms, Genetically Modified Primary Cell Culture Rats Rats, Sprague-Dawley Receptors, CXCR4 Signal Transduction Toxoplasma
spellingShingle	amino acid transporter B7 antigen chemokine receptor CXCR4 glutamine lipopolysaccharide phosphatidylinositol 3 kinase Rho kinase sodium dependent neutral amino acid transporter 2 stromal cell derived factor 1alpha unclassified drug amino acid transporter chemokine receptor CXCR4 CXCL12 protein, rat Cxcr4 protein, rat glutamine lipopolysaccharide luciferase SNAT2 protein, rat stromal cell derived factor 1 amino acid transport animal cell animal tissue Article bone marrow cell damage cell migration cell motility controlled study dendritic cell female host cell immunocompetent cell in vitro study intracellular signaling nonhuman parasite cultivation parasite viability phenotype protein expression protein protein interaction rat Toxoplasma gondii toxoplasmosis Western blotting animal bone marrow cell cell differentiation cell motion drug effects fibroblast gene expression regulation genetics host pathogen interaction human immunology metabolism newborn parasitology pathology primary cell culture reporter gene signal transduction Sprague Dawley rat Toxoplasma transgenic organism Toxoplasma gondii Amino Acid Transport Systems Animals Animals, Newborn Bone Marrow Cells Cell Differentiation Cell Movement Chemokine CXCL12 Dendritic Cells Fibroblasts Gene Expression Regulation Genes, Reporter Glutamine Host-Pathogen Interactions Humans Lipopolysaccharides Luciferases Organisms, Genetically Modified Primary Cell Culture Rats Rats, Sprague-Dawley Receptors, CXCR4 Signal Transduction Toxoplasma Lee I.-P. Evans A.K. Yang C. Works M.G. Kumar V. De Miguel Z. Manley N.C. Sapolsky R.M. Toxoplasma gondii is dependent on glutamine and alters migratory profile of infected host bone marrow derived immune cells through SNAT2 and CXCR4 pathways
description	10.1371/journal.pone.0109803
author2	DEPT OF PHARMACOLOGY
author_facet	DEPT OF PHARMACOLOGY Lee I.-P. Evans A.K. Yang C. Works M.G. Kumar V. De Miguel Z. Manley N.C. Sapolsky R.M.
format	Article
author	Lee I.-P. Evans A.K. Yang C. Works M.G. Kumar V. De Miguel Z. Manley N.C. Sapolsky R.M.
author_sort	Lee I.-P.
title	Toxoplasma gondii is dependent on glutamine and alters migratory profile of infected host bone marrow derived immune cells through SNAT2 and CXCR4 pathways
title_short	Toxoplasma gondii is dependent on glutamine and alters migratory profile of infected host bone marrow derived immune cells through SNAT2 and CXCR4 pathways
title_full	Toxoplasma gondii is dependent on glutamine and alters migratory profile of infected host bone marrow derived immune cells through SNAT2 and CXCR4 pathways
title_fullStr	Toxoplasma gondii is dependent on glutamine and alters migratory profile of infected host bone marrow derived immune cells through SNAT2 and CXCR4 pathways
title_full_unstemmed	Toxoplasma gondii is dependent on glutamine and alters migratory profile of infected host bone marrow derived immune cells through SNAT2 and CXCR4 pathways
title_sort	toxoplasma gondii is dependent on glutamine and alters migratory profile of infected host bone marrow derived immune cells through snat2 and cxcr4 pathways
publishDate	2019
url	https://scholarbank.nus.edu.sg/handle/10635/161770
_version_	1781791834119340032

Toxoplasma gondii is dependent on glutamine and alters migratory profile of infected host bone marrow derived immune cells through SNAT2 and CXCR4 pathways

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