Toxoplasma gondii is dependent on glutamine and alters migratory profile of infected host bone marrow derived immune cells through SNAT2 and CXCR4 pathways

10.1371/journal.pone.0109803

Saved in:

Bibliographic Details
Main Authors:	Lee I.-P., Evans A.K., Yang C., Works M.G., Kumar V., De Miguel Z., Manley N.C., Sapolsky R.M.
Other Authors:	DEPT OF PHARMACOLOGY
Format:	Article
Published:	2019
Subjects:	amino acid transporter B7 antigen chemokine receptor CXCR4 glutamine lipopolysaccharide phosphatidylinositol 3 kinase Rho kinase sodium dependent neutral amino acid transporter 2 stromal cell derived factor 1alpha unclassified drug CXCL12 protein, rat Cxcr4 protein, rat luciferase SNAT2 protein, rat stromal cell derived factor 1 amino acid transport animal cell animal tissue Article bone marrow cell damage cell migration cell motility controlled study dendritic cell female host cell immunocompetent cell in vitro study intracellular signaling nonhuman parasite cultivation parasite viability phenotype protein expression protein protein interaction rat Toxoplasma gondii toxoplasmosis Western blotting animal bone marrow cell cell differentiation cell motion drug effects fibroblast gene expression regulation genetics host pathogen interaction human immunology metabolism newborn parasitology pathology primary cell culture reporter gene signal transduction Sprague Dawley rat Toxoplasma transgenic organism Amino Acid Transport Systems Animals Animals, Newborn Bone Marrow Cells Cell Differentiation Cell Movement Chemokine CXCL12 Dendritic Cells Fibroblasts Gene Expression Regulation Genes, Reporter Glutamine Host-Pathogen Interactions Humans Lipopolysaccharides Luciferases Organisms, Genetically Modified Primary Cell Culture Rats Rats, Sprague-Dawley Receptors, CXCR4 Signal Transduction
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/161770
Tags:	Add Tag No Tags, Be the first to tag this record!
Institution:	National University of Singapore

Be the first to leave a comment!