The KDM2B-let-7b-EZH2 axis in myelodysplastic syndromes as a target for combined epigenetic therapy

• Main Authors: Karoopongse E., Yeung C., Byon J., Ramakrishnan A., Holman Z.J., Jiang P.Y.Z., Yu Q., Deeg H.J., Marcondes A.M.
• Other Authors: PHYSIOLOGY
• Format: Article
• Published: 2019
• Subjects: 3 deazaneplanocin A; azacitidine; cyclin D1; histone demethylase; microRNA; microRNA let 7b; protein KDM2B; protein p16; transcription factor EZH2; unclassified drug; EZH2 protein, human; F box protein; histone; KDM2A protein, human; mirnlet7 microRNA, human; polycomb repressive complex 2; Article; bone marrow culture; CD34 selection; cell cycle G0 phase; cell cycle G1 phase; cell cycle S phase; cell proliferation; controlled study; DNA methylation; epigenetics; gene overexpression; gene repression; gene silencing; genetic transcription; human; human cell; human tissue; myelodysplastic syndrome; protein blood level; protein expression; protein function; real time polymerase chain reaction; bone marrow cell; cluster analysis; drug effects; gene expression; gene expression profiling; genetic epigenesis; genetics; metabolism; methylation; molecularly targeted therapy; Myelodysplastic Syndromes; pathology; tumor cell line; Azacitidine; Bone Marrow Cells; Cell Line, Tumor; Cluster Analysis; Epigenesis, Genetic; F-Box Proteins; Gene Expression; Gene Expression Profiling; Gene Knockdown Techniques; Histones; Humans; Jumonji Domain-Containing Histone Demethylases; Methylation; MicroRNAs; Molecular Targeted Therapy; Polycomb Repressive Complex 2
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161772
• Institution: National University of Singapore

10.1371/journal.pone.0107817