The KDM2B-let-7b-EZH2 axis in myelodysplastic syndromes as a target for combined epigenetic therapy

10.1371/journal.pone.0107817

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Main Authors:	Karoopongse E., Yeung C., Byon J., Ramakrishnan A., Holman Z.J., Jiang P.Y.Z., Yu Q., Deeg H.J., Marcondes A.M.
Other Authors:	PHYSIOLOGY
Format:	Article
Published:	2019
Subjects:	3 deazaneplanocin A azacitidine cyclin D1 histone demethylase microRNA microRNA let 7b protein KDM2B protein p16 transcription factor EZH2 unclassified drug EZH2 protein, human F box protein histone KDM2A protein, human mirnlet7 microRNA, human polycomb repressive complex 2 Article bone marrow culture CD34 selection cell cycle G0 phase cell cycle G1 phase cell cycle S phase cell proliferation controlled study DNA methylation epigenetics gene overexpression gene repression gene silencing genetic transcription human human cell human tissue myelodysplastic syndrome protein blood level protein expression protein function real time polymerase chain reaction bone marrow cell cluster analysis drug effects gene expression gene expression profiling genetic epigenesis genetics metabolism methylation molecularly targeted therapy Myelodysplastic Syndromes pathology tumor cell line Azacitidine Bone Marrow Cells Cell Line, Tumor Cluster Analysis Epigenesis, Genetic F-Box Proteins Gene Expression Gene Expression Profiling Gene Knockdown Techniques Histones Humans Jumonji Domain-Containing Histone Demethylases Methylation MicroRNAs Molecular Targeted Therapy Polycomb Repressive Complex 2
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/161772
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1617722024-04-04T01:10:48Z The KDM2B-let-7b-EZH2 axis in myelodysplastic syndromes as a target for combined epigenetic therapy Karoopongse E. Yeung C. Byon J. Ramakrishnan A. Holman Z.J. Jiang P.Y.Z. Yu Q. Deeg H.J. Marcondes A.M. PHYSIOLOGY 3 deazaneplanocin A azacitidine cyclin D1 histone demethylase microRNA microRNA let 7b protein KDM2B protein p16 transcription factor EZH2 unclassified drug azacitidine EZH2 protein, human F box protein histone histone demethylase KDM2A protein, human microRNA mirnlet7 microRNA, human polycomb repressive complex 2 Article bone marrow culture CD34 selection cell cycle G0 phase cell cycle G1 phase cell cycle S phase cell proliferation controlled study DNA methylation epigenetics gene overexpression gene repression gene silencing genetic transcription human human cell human tissue myelodysplastic syndrome protein blood level protein expression protein function real time polymerase chain reaction bone marrow cell cluster analysis drug effects gene expression gene expression profiling genetic epigenesis genetics metabolism methylation molecularly targeted therapy Myelodysplastic Syndromes pathology tumor cell line Azacitidine Bone Marrow Cells Cell Line, Tumor Cluster Analysis Epigenesis, Genetic F-Box Proteins Gene Expression Gene Expression Profiling Gene Knockdown Techniques Histones Humans Jumonji Domain-Containing Histone Demethylases Methylation MicroRNAs Molecular Targeted Therapy Myelodysplastic Syndromes Polycomb Repressive Complex 2 10.1371/journal.pone.0107817 PLoS ONE 9 9 e107817 2019-11-07T05:07:23Z 2019-11-07T05:07:23Z 2014 Article Karoopongse E., Yeung C., Byon J., Ramakrishnan A., Holman Z.J., Jiang P.Y.Z., Yu Q., Deeg H.J., Marcondes A.M. (2014). The KDM2B-let-7b-EZH2 axis in myelodysplastic syndromes as a target for combined epigenetic therapy. PLoS ONE 9 (9) : e107817. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0107817 19326203 https://scholarbank.nus.edu.sg/handle/10635/161772 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Unpaywall 20191101
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	3 deazaneplanocin A azacitidine cyclin D1 histone demethylase microRNA microRNA let 7b protein KDM2B protein p16 transcription factor EZH2 unclassified drug azacitidine EZH2 protein, human F box protein histone histone demethylase KDM2A protein, human microRNA mirnlet7 microRNA, human polycomb repressive complex 2 Article bone marrow culture CD34 selection cell cycle G0 phase cell cycle G1 phase cell cycle S phase cell proliferation controlled study DNA methylation epigenetics gene overexpression gene repression gene silencing genetic transcription human human cell human tissue myelodysplastic syndrome protein blood level protein expression protein function real time polymerase chain reaction bone marrow cell cluster analysis drug effects gene expression gene expression profiling genetic epigenesis genetics metabolism methylation molecularly targeted therapy Myelodysplastic Syndromes pathology tumor cell line Azacitidine Bone Marrow Cells Cell Line, Tumor Cluster Analysis Epigenesis, Genetic F-Box Proteins Gene Expression Gene Expression Profiling Gene Knockdown Techniques Histones Humans Jumonji Domain-Containing Histone Demethylases Methylation MicroRNAs Molecular Targeted Therapy Myelodysplastic Syndromes Polycomb Repressive Complex 2
spellingShingle	3 deazaneplanocin A azacitidine cyclin D1 histone demethylase microRNA microRNA let 7b protein KDM2B protein p16 transcription factor EZH2 unclassified drug azacitidine EZH2 protein, human F box protein histone histone demethylase KDM2A protein, human microRNA mirnlet7 microRNA, human polycomb repressive complex 2 Article bone marrow culture CD34 selection cell cycle G0 phase cell cycle G1 phase cell cycle S phase cell proliferation controlled study DNA methylation epigenetics gene overexpression gene repression gene silencing genetic transcription human human cell human tissue myelodysplastic syndrome protein blood level protein expression protein function real time polymerase chain reaction bone marrow cell cluster analysis drug effects gene expression gene expression profiling genetic epigenesis genetics metabolism methylation molecularly targeted therapy Myelodysplastic Syndromes pathology tumor cell line Azacitidine Bone Marrow Cells Cell Line, Tumor Cluster Analysis Epigenesis, Genetic F-Box Proteins Gene Expression Gene Expression Profiling Gene Knockdown Techniques Histones Humans Jumonji Domain-Containing Histone Demethylases Methylation MicroRNAs Molecular Targeted Therapy Myelodysplastic Syndromes Polycomb Repressive Complex 2 Karoopongse E. Yeung C. Byon J. Ramakrishnan A. Holman Z.J. Jiang P.Y.Z. Yu Q. Deeg H.J. Marcondes A.M. The KDM2B-let-7b-EZH2 axis in myelodysplastic syndromes as a target for combined epigenetic therapy
description	10.1371/journal.pone.0107817
author2	PHYSIOLOGY
author_facet	PHYSIOLOGY Karoopongse E. Yeung C. Byon J. Ramakrishnan A. Holman Z.J. Jiang P.Y.Z. Yu Q. Deeg H.J. Marcondes A.M.
format	Article
author	Karoopongse E. Yeung C. Byon J. Ramakrishnan A. Holman Z.J. Jiang P.Y.Z. Yu Q. Deeg H.J. Marcondes A.M.
author_sort	Karoopongse E.
title	The KDM2B-let-7b-EZH2 axis in myelodysplastic syndromes as a target for combined epigenetic therapy
title_short	The KDM2B-let-7b-EZH2 axis in myelodysplastic syndromes as a target for combined epigenetic therapy
title_full	The KDM2B-let-7b-EZH2 axis in myelodysplastic syndromes as a target for combined epigenetic therapy
title_fullStr	The KDM2B-let-7b-EZH2 axis in myelodysplastic syndromes as a target for combined epigenetic therapy
title_full_unstemmed	The KDM2B-let-7b-EZH2 axis in myelodysplastic syndromes as a target for combined epigenetic therapy
title_sort	kdm2b-let-7b-ezh2 axis in myelodysplastic syndromes as a target for combined epigenetic therapy
publishDate	2019
url	https://scholarbank.nus.edu.sg/handle/10635/161772
_version_	1795374113462681600

The KDM2B-let-7b-EZH2 axis in myelodysplastic syndromes as a target for combined epigenetic therapy

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