The bile acid sensor FXR protects against dyslipidemia and aortic plaques development induced by the HIV protease inhibitor ritonavir in mice

10.1371/journal.pone.0013238

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Main Authors:	Mencarelli A., Cipriani S., Renga B., Francisci D., Palladino G., Distrutti E., Baldelli F., Fiorucci S.
Other Authors:	DEAN'S OFFICE (DUKE-NUS MEDICAL SCHOOL)
Format:	Article
Published:	2019
Subjects:	CD36 antigen chenodeoxycholic acid cholesterol farnesoid X receptor fatty acid synthase gemfibrozil ritonavir sterol regulatory element binding protein 1 triacylglycerol apolipoprotein E bile acid cell receptor farnesoid X-activated receptor Human immunodeficiency virus proteinase inhibitor animal cell animal experiment animal model animal tissue aorta atherosclerosis article cholesterol blood level cholesterol transport controlled study disease course dyslipidemia flow cytometry gene expression regulation histopathology lipid blood level lipid metabolism liver histology male monocyte mouse nonhuman protein function real time polymerase chain reaction Western blotting wild type animal aorta atherosclerosis cell line genetics metabolism mouse mutant pathology physiology Human immunodeficiency virus Mus Rodentia Animals Antigens, CD36 Aorta Apolipoproteins E Atherosclerosis Bile Acids and Salts Cell Line Dyslipidemias HIV Protease Inhibitors Mice Mice, Knockout Receptors, Cytoplasmic and Nuclear Ritonavir
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/161802
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1618022023-09-21T08:57:19Z The bile acid sensor FXR protects against dyslipidemia and aortic plaques development induced by the HIV protease inhibitor ritonavir in mice Mencarelli A. Cipriani S. Renga B. Francisci D. Palladino G. Distrutti E. Baldelli F. Fiorucci S. DEAN'S OFFICE (DUKE-NUS MEDICAL SCHOOL) DUKE-NUS MEDICAL SCHOOL CD36 antigen chenodeoxycholic acid cholesterol farnesoid X receptor fatty acid synthase gemfibrozil ritonavir sterol regulatory element binding protein 1 triacylglycerol apolipoprotein E bile acid cell receptor farnesoid X receptor farnesoid X-activated receptor Human immunodeficiency virus proteinase inhibitor ritonavir animal cell animal experiment animal model animal tissue aorta atherosclerosis article cholesterol blood level cholesterol transport controlled study disease course dyslipidemia flow cytometry gene expression regulation histopathology lipid blood level lipid metabolism liver histology male monocyte mouse nonhuman protein function real time polymerase chain reaction Western blotting wild type animal aorta atherosclerosis cell line dyslipidemia genetics metabolism mouse mutant pathology physiology Human immunodeficiency virus Mus Rodentia Animals Antigens, CD36 Aorta Apolipoproteins E Atherosclerosis Bile Acids and Salts Cell Line Dyslipidemias HIV Protease Inhibitors Mice Mice, Knockout Receptors, Cytoplasmic and Nuclear Ritonavir 10.1371/journal.pone.0013238 PLoS ONE 5 10 e13238 2019-11-07T08:00:01Z 2019-11-07T08:00:01Z 2010 Article Mencarelli A., Cipriani S., Renga B., Francisci D., Palladino G., Distrutti E., Baldelli F., Fiorucci S. (2010). The bile acid sensor FXR protects against dyslipidemia and aortic plaques development induced by the HIV protease inhibitor ritonavir in mice. PLoS ONE 5 (10) : e13238. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0013238 19326203 https://scholarbank.nus.edu.sg/handle/10635/161802 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Unpaywall 20191101
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	CD36 antigen chenodeoxycholic acid cholesterol farnesoid X receptor fatty acid synthase gemfibrozil ritonavir sterol regulatory element binding protein 1 triacylglycerol apolipoprotein E bile acid cell receptor farnesoid X receptor farnesoid X-activated receptor Human immunodeficiency virus proteinase inhibitor ritonavir animal cell animal experiment animal model animal tissue aorta atherosclerosis article cholesterol blood level cholesterol transport controlled study disease course dyslipidemia flow cytometry gene expression regulation histopathology lipid blood level lipid metabolism liver histology male monocyte mouse nonhuman protein function real time polymerase chain reaction Western blotting wild type animal aorta atherosclerosis cell line dyslipidemia genetics metabolism mouse mutant pathology physiology Human immunodeficiency virus Mus Rodentia Animals Antigens, CD36 Aorta Apolipoproteins E Atherosclerosis Bile Acids and Salts Cell Line Dyslipidemias HIV Protease Inhibitors Mice Mice, Knockout Receptors, Cytoplasmic and Nuclear Ritonavir
spellingShingle	CD36 antigen chenodeoxycholic acid cholesterol farnesoid X receptor fatty acid synthase gemfibrozil ritonavir sterol regulatory element binding protein 1 triacylglycerol apolipoprotein E bile acid cell receptor farnesoid X receptor farnesoid X-activated receptor Human immunodeficiency virus proteinase inhibitor ritonavir animal cell animal experiment animal model animal tissue aorta atherosclerosis article cholesterol blood level cholesterol transport controlled study disease course dyslipidemia flow cytometry gene expression regulation histopathology lipid blood level lipid metabolism liver histology male monocyte mouse nonhuman protein function real time polymerase chain reaction Western blotting wild type animal aorta atherosclerosis cell line dyslipidemia genetics metabolism mouse mutant pathology physiology Human immunodeficiency virus Mus Rodentia Animals Antigens, CD36 Aorta Apolipoproteins E Atherosclerosis Bile Acids and Salts Cell Line Dyslipidemias HIV Protease Inhibitors Mice Mice, Knockout Receptors, Cytoplasmic and Nuclear Ritonavir Mencarelli A. Cipriani S. Renga B. Francisci D. Palladino G. Distrutti E. Baldelli F. Fiorucci S. The bile acid sensor FXR protects against dyslipidemia and aortic plaques development induced by the HIV protease inhibitor ritonavir in mice
description	10.1371/journal.pone.0013238
author2	DEAN'S OFFICE (DUKE-NUS MEDICAL SCHOOL)
author_facet	DEAN'S OFFICE (DUKE-NUS MEDICAL SCHOOL) Mencarelli A. Cipriani S. Renga B. Francisci D. Palladino G. Distrutti E. Baldelli F. Fiorucci S.
format	Article
author	Mencarelli A. Cipriani S. Renga B. Francisci D. Palladino G. Distrutti E. Baldelli F. Fiorucci S.
author_sort	Mencarelli A.
title	The bile acid sensor FXR protects against dyslipidemia and aortic plaques development induced by the HIV protease inhibitor ritonavir in mice
title_short	The bile acid sensor FXR protects against dyslipidemia and aortic plaques development induced by the HIV protease inhibitor ritonavir in mice
title_full	The bile acid sensor FXR protects against dyslipidemia and aortic plaques development induced by the HIV protease inhibitor ritonavir in mice
title_fullStr	The bile acid sensor FXR protects against dyslipidemia and aortic plaques development induced by the HIV protease inhibitor ritonavir in mice
title_full_unstemmed	The bile acid sensor FXR protects against dyslipidemia and aortic plaques development induced by the HIV protease inhibitor ritonavir in mice
title_sort	bile acid sensor fxr protects against dyslipidemia and aortic plaques development induced by the hiv protease inhibitor ritonavir in mice
publishDate	2019
url	https://scholarbank.nus.edu.sg/handle/10635/161802
_version_	1778169221755174912

The bile acid sensor FXR protects against dyslipidemia and aortic plaques development induced by the HIV protease inhibitor ritonavir in mice

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