The bile acid sensor FXR protects against dyslipidemia and aortic plaques development induced by the HIV protease inhibitor ritonavir in mice

• Main Authors: Mencarelli A., Cipriani S., Renga B., Francisci D., Palladino G., Distrutti E., Baldelli F., Fiorucci S.
• Other Authors: DEAN'S OFFICE (DUKE-NUS MEDICAL SCHOOL)
• Format: Article
• Published: 2019
• Subjects: CD36 antigen; chenodeoxycholic acid; cholesterol; farnesoid X receptor; fatty acid synthase; gemfibrozil; ritonavir; sterol regulatory element binding protein 1; triacylglycerol; apolipoprotein E; bile acid; cell receptor; farnesoid X-activated receptor; Human immunodeficiency virus proteinase inhibitor; animal cell; animal experiment; animal model; animal tissue; aorta atherosclerosis; article; cholesterol blood level; cholesterol transport; controlled study; disease course; dyslipidemia; flow cytometry; gene expression regulation; histopathology; lipid blood level; lipid metabolism; liver histology; male; monocyte; mouse; nonhuman; protein function; real time polymerase chain reaction; Western blotting; wild type; animal; aorta; atherosclerosis; cell line; genetics; metabolism; mouse mutant; pathology; physiology; Human immunodeficiency virus; Mus; Rodentia; Animals; Antigens, CD36; Aorta; Apolipoproteins E; Atherosclerosis; Bile Acids and Salts; Cell Line; Dyslipidemias; HIV Protease Inhibitors; Mice; Mice, Knockout; Receptors, Cytoplasmic and Nuclear; Ritonavir
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161802
• Institution: National University of Singapore

10.1371/journal.pone.0013238