Characterization of notch1 antibodies that inhibit signaling of both normal and mutated notch1 receptors

10.1371/journal.pone.0009094

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Main Authors:	Aste-Am閦aga M., Zhang N., Lineberger J.E., Arnold B.A., Toner T.J., Gu M., Huang L., Vitelli S., Vo K.T., Haytko P., Zhao J.Z., Baleydier F., L'Heureux S., Wang H., Gordon W.R., Thoryk E., Andrawes M.B., Tiyanont K., Stegmaier K., Roti G., Ross K.N., Franlin L.L., Wang F., Chastain M., Bett A.J., Audoly L.P., Aster J.C., Blacklow S.C., Huber H.E.
Other Authors:	DUKE-NUS MEDICAL SCHOOL
Format:	Article
Published:	2019
Subjects:	epidermal growth factor gamma secretase inhibitor metalloproteinase monoclonal antibody monoclonal antibody Notch1 Notch1 receptor Notch2 receptor Notch3 receptor Notch4 receptor transcription factor HES 1 transcription factor HES 5 unclassified drug JAG2 protein, human ligand membrane protein signal peptide acute lymphoblastic leukemia angiogenesis article controlled study deltex1 gene gene gene expression human human cell ligand binding phage display point mutation protein domain reporter gene T lymphocyte tumor cell line animal antibody specificity binding competition binding site cell line cell proliferation cell strain 3T3 drug effect flow cytometry gene expression regulation genetics immunology metabolism mouse mutation pathology reverse transcription polymerase chain reaction signal transduction Metazoa 3T3 Cells Animals Antibodies, Monoclonal Antibody Specificity Binding Sites Binding, Competitive Cell Line Cell Line, Tumor Cell Proliferation Flow Cytometry Gene Expression Regulation, Neoplastic Humans Intercellular Signaling Peptides and Proteins Ligands Membrane Proteins Mice Mutation Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Receptor, Notch1 Reverse Transcriptase Polymerase Chain Reaction Signal Transduction
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/161817
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1618172023-10-31T09:10:09Z Characterization of notch1 antibodies that inhibit signaling of both normal and mutated notch1 receptors Aste-Am閦aga M. Zhang N. Lineberger J.E. Arnold B.A. Toner T.J. Gu M. Huang L. Vitelli S. Vo K.T. Haytko P. Zhao J.Z. Baleydier F. L'Heureux S. Wang H. Gordon W.R. Thoryk E. Andrawes M.B. Tiyanont K. Stegmaier K. Roti G. Ross K.N. Franlin L.L. Wang H. Wang F. Chastain M. Bett A.J. Audoly L.P. Aster J.C. Blacklow S.C. Huber H.E. DUKE-NUS MEDICAL SCHOOL epidermal growth factor gamma secretase inhibitor metalloproteinase monoclonal antibody monoclonal antibody Notch1 Notch1 receptor Notch2 receptor Notch3 receptor Notch4 receptor transcription factor HES 1 transcription factor HES 5 unclassified drug JAG2 protein, human ligand membrane protein monoclonal antibody Notch1 receptor signal peptide acute lymphoblastic leukemia angiogenesis article controlled study deltex1 gene gene gene expression human human cell ligand binding phage display point mutation protein domain reporter gene T lymphocyte tumor cell line animal antibody specificity binding competition binding site cell line cell proliferation cell strain 3T3 drug effect flow cytometry gene expression regulation genetics immunology metabolism mouse mutation pathology reverse transcription polymerase chain reaction signal transduction Metazoa 3T3 Cells Animals Antibodies, Monoclonal Antibody Specificity Binding Sites Binding, Competitive Cell Line Cell Line, Tumor Cell Proliferation Flow Cytometry Gene Expression Regulation, Neoplastic Humans Intercellular Signaling Peptides and Proteins Ligands Membrane Proteins Mice Mutation Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Receptor, Notch1 Reverse Transcriptase Polymerase Chain Reaction Signal Transduction 10.1371/journal.pone.0009094 PLoS ONE 5 2 e9094 2019-11-07T08:14:07Z 2019-11-07T08:14:07Z 2010 Article Aste-Am閦aga M., Zhang N., Lineberger J.E., Arnold B.A., Toner T.J., Gu M., Huang L., Vitelli S., Vo K.T., Haytko P., Zhao J.Z., Baleydier F., L'Heureux S., Wang H., Gordon W.R., Thoryk E., Andrawes M.B., Tiyanont K., Stegmaier K., Roti G., Ross K.N., Franlin L.L., Wang H., Wang F., Chastain M., Bett A.J., Audoly L.P., Aster J.C., Blacklow S.C., Huber H.E. (2010). Characterization of notch1 antibodies that inhibit signaling of both normal and mutated notch1 receptors. PLoS ONE 5 (2) : e9094. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0009094 19326203 https://scholarbank.nus.edu.sg/handle/10635/161817 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Unpaywall 20191101
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	epidermal growth factor gamma secretase inhibitor metalloproteinase monoclonal antibody monoclonal antibody Notch1 Notch1 receptor Notch2 receptor Notch3 receptor Notch4 receptor transcription factor HES 1 transcription factor HES 5 unclassified drug JAG2 protein, human ligand membrane protein monoclonal antibody Notch1 receptor signal peptide acute lymphoblastic leukemia angiogenesis article controlled study deltex1 gene gene gene expression human human cell ligand binding phage display point mutation protein domain reporter gene T lymphocyte tumor cell line animal antibody specificity binding competition binding site cell line cell proliferation cell strain 3T3 drug effect flow cytometry gene expression regulation genetics immunology metabolism mouse mutation pathology reverse transcription polymerase chain reaction signal transduction Metazoa 3T3 Cells Animals Antibodies, Monoclonal Antibody Specificity Binding Sites Binding, Competitive Cell Line Cell Line, Tumor Cell Proliferation Flow Cytometry Gene Expression Regulation, Neoplastic Humans Intercellular Signaling Peptides and Proteins Ligands Membrane Proteins Mice Mutation Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Receptor, Notch1 Reverse Transcriptase Polymerase Chain Reaction Signal Transduction
spellingShingle	epidermal growth factor gamma secretase inhibitor metalloproteinase monoclonal antibody monoclonal antibody Notch1 Notch1 receptor Notch2 receptor Notch3 receptor Notch4 receptor transcription factor HES 1 transcription factor HES 5 unclassified drug JAG2 protein, human ligand membrane protein monoclonal antibody Notch1 receptor signal peptide acute lymphoblastic leukemia angiogenesis article controlled study deltex1 gene gene gene expression human human cell ligand binding phage display point mutation protein domain reporter gene T lymphocyte tumor cell line animal antibody specificity binding competition binding site cell line cell proliferation cell strain 3T3 drug effect flow cytometry gene expression regulation genetics immunology metabolism mouse mutation pathology reverse transcription polymerase chain reaction signal transduction Metazoa 3T3 Cells Animals Antibodies, Monoclonal Antibody Specificity Binding Sites Binding, Competitive Cell Line Cell Line, Tumor Cell Proliferation Flow Cytometry Gene Expression Regulation, Neoplastic Humans Intercellular Signaling Peptides and Proteins Ligands Membrane Proteins Mice Mutation Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Receptor, Notch1 Reverse Transcriptase Polymerase Chain Reaction Signal Transduction Aste-Am閦aga M. Zhang N. Lineberger J.E. Arnold B.A. Toner T.J. Gu M. Huang L. Vitelli S. Vo K.T. Haytko P. Zhao J.Z. Baleydier F. L'Heureux S. Wang H. Gordon W.R. Thoryk E. Andrawes M.B. Tiyanont K. Stegmaier K. Roti G. Ross K.N. Franlin L.L. Wang H. Wang F. Chastain M. Bett A.J. Audoly L.P. Aster J.C. Blacklow S.C. Huber H.E. Characterization of notch1 antibodies that inhibit signaling of both normal and mutated notch1 receptors
description	10.1371/journal.pone.0009094
author2	DUKE-NUS MEDICAL SCHOOL
author_facet	DUKE-NUS MEDICAL SCHOOL Aste-Am閦aga M. Zhang N. Lineberger J.E. Arnold B.A. Toner T.J. Gu M. Huang L. Vitelli S. Vo K.T. Haytko P. Zhao J.Z. Baleydier F. L'Heureux S. Wang H. Gordon W.R. Thoryk E. Andrawes M.B. Tiyanont K. Stegmaier K. Roti G. Ross K.N. Franlin L.L. Wang H. Wang F. Chastain M. Bett A.J. Audoly L.P. Aster J.C. Blacklow S.C. Huber H.E.
format	Article
author	Aste-Am閦aga M. Zhang N. Lineberger J.E. Arnold B.A. Toner T.J. Gu M. Huang L. Vitelli S. Vo K.T. Haytko P. Zhao J.Z. Baleydier F. L'Heureux S. Wang H. Gordon W.R. Thoryk E. Andrawes M.B. Tiyanont K. Stegmaier K. Roti G. Ross K.N. Franlin L.L. Wang H. Wang F. Chastain M. Bett A.J. Audoly L.P. Aster J.C. Blacklow S.C. Huber H.E.
author_sort	Aste-Am閦aga M.
title	Characterization of notch1 antibodies that inhibit signaling of both normal and mutated notch1 receptors
title_short	Characterization of notch1 antibodies that inhibit signaling of both normal and mutated notch1 receptors
title_full	Characterization of notch1 antibodies that inhibit signaling of both normal and mutated notch1 receptors
title_fullStr	Characterization of notch1 antibodies that inhibit signaling of both normal and mutated notch1 receptors
title_full_unstemmed	Characterization of notch1 antibodies that inhibit signaling of both normal and mutated notch1 receptors
title_sort	characterization of notch1 antibodies that inhibit signaling of both normal and mutated notch1 receptors
publishDate	2019
url	https://scholarbank.nus.edu.sg/handle/10635/161817
_version_	1781791836830957568

Characterization of notch1 antibodies that inhibit signaling of both normal and mutated notch1 receptors

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