Characterization of notch1 antibodies that inhibit signaling of both normal and mutated notch1 receptors

• Main Authors: Aste-Am閦aga M., Zhang N., Lineberger J.E., Arnold B.A., Toner T.J., Gu M., Huang L., Vitelli S., Vo K.T., Haytko P., Zhao J.Z., Baleydier F., L'Heureux S., Wang H., Gordon W.R., Thoryk E., Andrawes M.B., Tiyanont K., Stegmaier K., Roti G., Ross K.N., Franlin L.L., Wang F., Chastain M., Bett A.J., Audoly L.P., Aster J.C., Blacklow S.C., Huber H.E.
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: 2019
• Subjects: epidermal growth factor; gamma secretase inhibitor; metalloproteinase; monoclonal antibody; monoclonal antibody Notch1; Notch1 receptor; Notch2 receptor; Notch3 receptor; Notch4 receptor; transcription factor HES 1; transcription factor HES 5; unclassified drug; JAG2 protein, human; ligand; membrane protein; signal peptide; acute lymphoblastic leukemia; angiogenesis; article; controlled study; deltex1 gene; gene; gene expression; human; human cell; ligand binding; phage display; point mutation; protein domain; reporter gene; T lymphocyte; tumor cell line; animal; antibody specificity; binding competition; binding site; cell line; cell proliferation; cell strain 3T3; drug effect; flow cytometry; gene expression regulation; genetics; immunology; metabolism; mouse; mutation; pathology; reverse transcription polymerase chain reaction; signal transduction; Metazoa; 3T3 Cells; Animals; Antibodies, Monoclonal; Antibody Specificity; Binding Sites; Binding, Competitive; Cell Line; Cell Line, Tumor; Cell Proliferation; Flow Cytometry; Gene Expression Regulation, Neoplastic; Humans; Intercellular Signaling Peptides and Proteins; Ligands; Membrane Proteins; Mice; Mutation; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Receptor, Notch1; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161817
• Institution: National University of Singapore

10.1371/journal.pone.0009094