Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway
10.1371/journal.pone.0006189
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sg-nus-scholar.10635-1618362024-04-03T07:38:34Z Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway Zhang H.H. Huang J. D黺el K. Boback B. Wu S. Squillance R.M. Wu C.-L. Manning B.D. PATHOLOGY insulin mammalian target of rapamycin messenger RNA peroxisome proliferator activated receptor gamma protein kinase B triacylglycerol tuberin insulin messenger RNA mTORC1 protein, mouse peroxisome proliferator activated receptor gamma transcription factor tuberin tumor suppressor protein adipocyte adipogenesis adipose tissue angiomyolipoma animal cell article cell differentiation cell strain 3T3 controlled study embryo enzyme activation enzyme activity enzyme phosphorylation fibroblast culture hormonal regulation hormone action human human cell human tissue insulin resistance kidney tumor mouse nonhuman protein expression protein protein interaction protein targeting signal transduction smooth muscle tuberous sclerosis adipocyte animal cell division cytology drug effect gene silencing genetics immunohistochemistry phosphorylation physiology Western blotting Mammalia 3T3-L1 Cells Adipocytes Animals Blotting, Western Cell Division Gene Knockdown Techniques Humans Immunohistochemistry Insulin Mice Phosphorylation PPAR gamma Proto-Oncogene Proteins c-akt RNA, Messenger Signal Transduction Transcription Factors Tumor Suppressor Proteins 10.1371/journal.pone.0006189 PLoS ONE 4 7 e6189 2019-11-08T00:52:38Z 2019-11-08T00:52:38Z 2009 Article Zhang H.H., Huang J., D黺el K., Boback B., Wu S., Squillance R.M., Wu C.-L., Manning B.D. (2009). Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway. PLoS ONE 4 (7) : e6189. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0006189 19326203 https://scholarbank.nus.edu.sg/handle/10635/161836 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Unpaywall 20191101 |
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insulin mammalian target of rapamycin messenger RNA peroxisome proliferator activated receptor gamma protein kinase B triacylglycerol tuberin insulin messenger RNA mTORC1 protein, mouse peroxisome proliferator activated receptor gamma transcription factor tuberin tumor suppressor protein adipocyte adipogenesis adipose tissue angiomyolipoma animal cell article cell differentiation cell strain 3T3 controlled study embryo enzyme activation enzyme activity enzyme phosphorylation fibroblast culture hormonal regulation hormone action human human cell human tissue insulin resistance kidney tumor mouse nonhuman protein expression protein protein interaction protein targeting signal transduction smooth muscle tuberous sclerosis adipocyte animal cell division cytology drug effect gene silencing genetics immunohistochemistry phosphorylation physiology Western blotting Mammalia 3T3-L1 Cells Adipocytes Animals Blotting, Western Cell Division Gene Knockdown Techniques Humans Immunohistochemistry Insulin Mice Phosphorylation PPAR gamma Proto-Oncogene Proteins c-akt RNA, Messenger Signal Transduction Transcription Factors Tumor Suppressor Proteins |
| spellingShingle |
insulin mammalian target of rapamycin messenger RNA peroxisome proliferator activated receptor gamma protein kinase B triacylglycerol tuberin insulin messenger RNA mTORC1 protein, mouse peroxisome proliferator activated receptor gamma transcription factor tuberin tumor suppressor protein adipocyte adipogenesis adipose tissue angiomyolipoma animal cell article cell differentiation cell strain 3T3 controlled study embryo enzyme activation enzyme activity enzyme phosphorylation fibroblast culture hormonal regulation hormone action human human cell human tissue insulin resistance kidney tumor mouse nonhuman protein expression protein protein interaction protein targeting signal transduction smooth muscle tuberous sclerosis adipocyte animal cell division cytology drug effect gene silencing genetics immunohistochemistry phosphorylation physiology Western blotting Mammalia 3T3-L1 Cells Adipocytes Animals Blotting, Western Cell Division Gene Knockdown Techniques Humans Immunohistochemistry Insulin Mice Phosphorylation PPAR gamma Proto-Oncogene Proteins c-akt RNA, Messenger Signal Transduction Transcription Factors Tumor Suppressor Proteins Zhang H.H. Huang J. D黺el K. Boback B. Wu S. Squillance R.M. Wu C.-L. Manning B.D. Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway |
| description |
10.1371/journal.pone.0006189 |
| author2 |
PATHOLOGY |
| author_facet |
PATHOLOGY Zhang H.H. Huang J. D黺el K. Boback B. Wu S. Squillance R.M. Wu C.-L. Manning B.D. |
| format |
Article |
| author |
Zhang H.H. Huang J. D黺el K. Boback B. Wu S. Squillance R.M. Wu C.-L. Manning B.D. |
| author_sort |
Zhang H.H. |
| title |
Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway |
| title_short |
Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway |
| title_full |
Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway |
| title_fullStr |
Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway |
| title_full_unstemmed |
Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway |
| title_sort |
insulin stimulates adipogenesis through the akt-tsc2-mtorc1 pathway |
| publishDate |
2019 |
| url |
https://scholarbank.nus.edu.sg/handle/10635/161836 |
| _version_ |
1795374116006526976 |