Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway

• Main Authors: Zhang H.H., Huang J., D黺el K., Boback B., Wu S., Squillance R.M., Wu C.-L., Manning B.D.
• Other Authors: PATHOLOGY
• Format: Article
• Published: 2019
• Subjects: insulin; mammalian target of rapamycin; messenger RNA; peroxisome proliferator activated receptor gamma; protein kinase B; triacylglycerol; tuberin; mTORC1 protein, mouse; transcription factor; tumor suppressor protein; adipocyte; adipogenesis; adipose tissue; angiomyolipoma; animal cell; article; cell differentiation; cell strain 3T3; controlled study; embryo; enzyme activation; enzyme activity; enzyme phosphorylation; fibroblast culture; hormonal regulation; hormone action; human; human cell; human tissue; insulin resistance; kidney tumor; mouse; nonhuman; protein expression; protein protein interaction; protein targeting; signal transduction; smooth muscle; tuberous sclerosis; animal; cell division; cytology; drug effect; gene silencing; genetics; immunohistochemistry; phosphorylation; physiology; Western blotting; Mammalia; 3T3-L1 Cells; Adipocytes; Animals; Blotting, Western; Cell Division; Gene Knockdown Techniques; Humans; Immunohistochemistry; Insulin; Mice; Phosphorylation; PPAR gamma; Proto-Oncogene Proteins c-akt; RNA, Messenger; Signal Transduction; Transcription Factors; Tumor Suppressor Proteins
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161836
• Institution: National University of Singapore

10.1371/journal.pone.0006189