Mitochondrial DNA variants of respiratory complex I that uniquely characterize haplogroup T2 are associated with increased risk of age-related macular degeneration

• Main Authors: SanGiovanni J.P., Arking D.E., Iyengar S.K., Elashoff M., Clemons T.E., Reed G.F., Henning A.K., Sivakumaran T.A., Xu X., DeWan A., Agr髇 E., Rochtchina E., Sue C.M., Wang J.J., Mitchell P., Hoh J., Francis P.J., Klein M.L., Chew E.Y., Chakravarti A.
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: 2019
• Subjects: mitochondrial DNA; reduced nicotinamide adenine dinucleotide dehydrogenase (ubiquinone); adult; aged; article; controlled study; female; gene locus; gene sequence; genetic analysis; genetic association; genetic variability; genotype; haplotype; human; inheritance; major clinical study; male; retina macula age related degeneration; risk assessment; single nucleotide polymorphism; age distribution; gene frequency; genetic predisposition; genetics; middle aged; mutation; retina macula degeneration; sex ratio; Age Distribution; Aged; Aged, 80 and over; DNA, Mitochondrial; Electron Transport Complex I; Female; Gene Frequency; Genetic Predisposition to Disease; Haplotypes; Humans; Macular Degeneration; Male; Middle Aged; Mutation; Sex Distribution
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161839
• Institution: National University of Singapore

10.1371/journal.pone.0005508