Natural terpenes prevent mitochondrial dysfunction, oxidative stress and release of apoptotic proteins during nimesulide-hepatotoxicity in rats

• Main Authors: Singh B.K., Tripathi M., Chaudhari B.P., Pandey P.K., Kakkar P.
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: 2019
• Subjects: 8 hydroxyguanine; alanine aminotransferase; apoptosis inducing factor; aspartate aminotransferase; bilirubin; biological marker; camphene; caspase 3; caspase 9; copper zinc superoxide dismutase; cytochrome c; DNA; endonuclease G; geraniol; glutathione; glutathione peroxidase; glutathione reductase; inducible nitric oxide synthase; manganese superoxide dismutase; messenger RNA; mitochondrial nitric oxide synthase; neuronal nitric oxide synthase; nimesulide; reactive nitrogen species; reactive oxygen metabolite; reduced nicotinamide adenine dinucleotide phosphate; silymarin; terpene derivative; unclassified drug; antioxidant; apoptosis regulatory protein; biological product; nucleotide; oxidizing agent; sulfonamide; terpene; alanine aminotransferase blood level; animal cell; animal experiment; animal model; animal tissue; antioxidant activity; article; aspartate aminotransferase blood level; bilirubin blood level; body weight; cell membrane permeability; controlled study; disorders of mitochondrial functions; DNA damage; drug megadose; drug structure; enzyme activity; enzyme inhibition; histopathology; immunoblotting; in vivo study; liver toxicity; macromolecule; male; membrane depolarization; mitochondrial energy transfer; mitochondrion swelling; molecular mechanics; nonhuman; oxidative stress; protein expression; protein secretion; protein synthesis inhibition; rat; Sprague Dawley rat; structure analysis; animal; cell death; cell protection; cytology; drug effect; electron transport; genetic transcription; homeostasis; lipid metabolism; liver; metabolism; mitochondrial membrane potential; mitochondrion; pathology; permeability; protein degradation; secretion; Rattus; Animals; Antioxidants; Apoptosis Regulatory Proteins; Biological Agents; Caspase 3; Caspase 9; Cell Death; Cytoprotection; DNA Damage; Electron Transport; Homeostasis; Lipid Metabolism; Liver; Male; Membrane Potential, Mitochondrial; Mitochondria; Nucleotides; Oxidants; Oxidative Stress; Permeability; Proteolysis; Rats; Rats, Sprague-Dawley; Sulfonamides; Terpenes; Transcription, Genetic
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161990
• Institution: National University of Singapore

10.1371/journal.pone.0034200