Natural terpenes prevent mitochondrial dysfunction, oxidative stress and release of apoptotic proteins during nimesulide-hepatotoxicity in rats

10.1371/journal.pone.0034200

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Main Authors:	Singh B.K., Tripathi M., Chaudhari B.P., Pandey P.K., Kakkar P.
Other Authors:	DUKE-NUS MEDICAL SCHOOL
Format:	Article
Published:	2019
Subjects:	8 hydroxyguanine alanine aminotransferase apoptosis inducing factor aspartate aminotransferase bilirubin biological marker camphene caspase 3 caspase 9 copper zinc superoxide dismutase cytochrome c DNA endonuclease G geraniol glutathione glutathione peroxidase glutathione reductase inducible nitric oxide synthase manganese superoxide dismutase messenger RNA mitochondrial nitric oxide synthase neuronal nitric oxide synthase nimesulide reactive nitrogen species reactive oxygen metabolite reduced nicotinamide adenine dinucleotide phosphate silymarin terpene derivative unclassified drug antioxidant apoptosis regulatory protein biological product nucleotide oxidizing agent sulfonamide terpene alanine aminotransferase blood level animal cell animal experiment animal model animal tissue antioxidant activity article aspartate aminotransferase blood level bilirubin blood level body weight cell membrane permeability controlled study disorders of mitochondrial functions DNA damage drug megadose drug structure enzyme activity enzyme inhibition histopathology immunoblotting in vivo study liver toxicity macromolecule male membrane depolarization mitochondrial energy transfer mitochondrion swelling molecular mechanics nonhuman oxidative stress protein expression protein secretion protein synthesis inhibition rat Sprague Dawley rat structure analysis animal cell death cell protection cytology drug effect electron transport genetic transcription homeostasis lipid metabolism liver metabolism mitochondrial membrane potential mitochondrion pathology permeability protein degradation secretion Rattus Animals Antioxidants Apoptosis Regulatory Proteins Biological Agents Caspase 3 Caspase 9 Cell Death Cytoprotection DNA Damage Electron Transport Homeostasis Lipid Metabolism Liver Male Membrane Potential, Mitochondrial Mitochondria Nucleotides Oxidants Oxidative Stress Permeability Proteolysis Rats Rats, Sprague-Dawley Sulfonamides Terpenes Transcription, Genetic
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/161990
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1619902023-10-31T20:59:12Z Natural terpenes prevent mitochondrial dysfunction, oxidative stress and release of apoptotic proteins during nimesulide-hepatotoxicity in rats Singh B.K. Tripathi M. Chaudhari B.P. Pandey P.K. Kakkar P. DUKE-NUS MEDICAL SCHOOL NUSHS PROJECT 8 hydroxyguanine alanine aminotransferase apoptosis inducing factor aspartate aminotransferase bilirubin biological marker camphene caspase 3 caspase 9 copper zinc superoxide dismutase cytochrome c DNA endonuclease G geraniol glutathione glutathione peroxidase glutathione reductase inducible nitric oxide synthase manganese superoxide dismutase messenger RNA mitochondrial nitric oxide synthase neuronal nitric oxide synthase nimesulide reactive nitrogen species reactive oxygen metabolite reduced nicotinamide adenine dinucleotide phosphate silymarin terpene derivative unclassified drug antioxidant apoptosis regulatory protein biological product caspase 3 caspase 9 nimesulide nucleotide oxidizing agent sulfonamide terpene alanine aminotransferase blood level animal cell animal experiment animal model animal tissue antioxidant activity article aspartate aminotransferase blood level bilirubin blood level body weight cell membrane permeability controlled study disorders of mitochondrial functions DNA damage drug megadose drug structure enzyme activity enzyme inhibition histopathology immunoblotting in vivo study liver toxicity macromolecule male membrane depolarization mitochondrial energy transfer mitochondrion swelling molecular mechanics nonhuman oxidative stress protein expression protein secretion protein synthesis inhibition rat Sprague Dawley rat structure analysis animal cell death cell protection cytology drug effect electron transport genetic transcription homeostasis lipid metabolism liver metabolism mitochondrial membrane potential mitochondrion pathology permeability protein degradation secretion Rattus Animals Antioxidants Apoptosis Regulatory Proteins Biological Agents Caspase 3 Caspase 9 Cell Death Cytoprotection DNA Damage Electron Transport Homeostasis Lipid Metabolism Liver Male Membrane Potential, Mitochondrial Mitochondria Nucleotides Oxidants Oxidative Stress Permeability Proteolysis Rats Rats, Sprague-Dawley Sulfonamides Terpenes Transcription, Genetic 10.1371/journal.pone.0034200 PLoS ONE 7 4 e34200 2019-11-11T06:40:43Z 2019-11-11T06:40:43Z 2012 Article Singh B.K., Tripathi M., Chaudhari B.P., Pandey P.K., Kakkar P. (2012). Natural terpenes prevent mitochondrial dysfunction, oxidative stress and release of apoptotic proteins during nimesulide-hepatotoxicity in rats. PLoS ONE 7 (4) : e34200. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0034200 19326203 https://scholarbank.nus.edu.sg/handle/10635/161990 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Unpaywall 20191101
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	8 hydroxyguanine alanine aminotransferase apoptosis inducing factor aspartate aminotransferase bilirubin biological marker camphene caspase 3 caspase 9 copper zinc superoxide dismutase cytochrome c DNA endonuclease G geraniol glutathione glutathione peroxidase glutathione reductase inducible nitric oxide synthase manganese superoxide dismutase messenger RNA mitochondrial nitric oxide synthase neuronal nitric oxide synthase nimesulide reactive nitrogen species reactive oxygen metabolite reduced nicotinamide adenine dinucleotide phosphate silymarin terpene derivative unclassified drug antioxidant apoptosis regulatory protein biological product caspase 3 caspase 9 nimesulide nucleotide oxidizing agent sulfonamide terpene alanine aminotransferase blood level animal cell animal experiment animal model animal tissue antioxidant activity article aspartate aminotransferase blood level bilirubin blood level body weight cell membrane permeability controlled study disorders of mitochondrial functions DNA damage drug megadose drug structure enzyme activity enzyme inhibition histopathology immunoblotting in vivo study liver toxicity macromolecule male membrane depolarization mitochondrial energy transfer mitochondrion swelling molecular mechanics nonhuman oxidative stress protein expression protein secretion protein synthesis inhibition rat Sprague Dawley rat structure analysis animal cell death cell protection cytology drug effect electron transport genetic transcription homeostasis lipid metabolism liver metabolism mitochondrial membrane potential mitochondrion pathology permeability protein degradation secretion Rattus Animals Antioxidants Apoptosis Regulatory Proteins Biological Agents Caspase 3 Caspase 9 Cell Death Cytoprotection DNA Damage Electron Transport Homeostasis Lipid Metabolism Liver Male Membrane Potential, Mitochondrial Mitochondria Nucleotides Oxidants Oxidative Stress Permeability Proteolysis Rats Rats, Sprague-Dawley Sulfonamides Terpenes Transcription, Genetic
spellingShingle	8 hydroxyguanine alanine aminotransferase apoptosis inducing factor aspartate aminotransferase bilirubin biological marker camphene caspase 3 caspase 9 copper zinc superoxide dismutase cytochrome c DNA endonuclease G geraniol glutathione glutathione peroxidase glutathione reductase inducible nitric oxide synthase manganese superoxide dismutase messenger RNA mitochondrial nitric oxide synthase neuronal nitric oxide synthase nimesulide reactive nitrogen species reactive oxygen metabolite reduced nicotinamide adenine dinucleotide phosphate silymarin terpene derivative unclassified drug antioxidant apoptosis regulatory protein biological product caspase 3 caspase 9 nimesulide nucleotide oxidizing agent sulfonamide terpene alanine aminotransferase blood level animal cell animal experiment animal model animal tissue antioxidant activity article aspartate aminotransferase blood level bilirubin blood level body weight cell membrane permeability controlled study disorders of mitochondrial functions DNA damage drug megadose drug structure enzyme activity enzyme inhibition histopathology immunoblotting in vivo study liver toxicity macromolecule male membrane depolarization mitochondrial energy transfer mitochondrion swelling molecular mechanics nonhuman oxidative stress protein expression protein secretion protein synthesis inhibition rat Sprague Dawley rat structure analysis animal cell death cell protection cytology drug effect electron transport genetic transcription homeostasis lipid metabolism liver metabolism mitochondrial membrane potential mitochondrion pathology permeability protein degradation secretion Rattus Animals Antioxidants Apoptosis Regulatory Proteins Biological Agents Caspase 3 Caspase 9 Cell Death Cytoprotection DNA Damage Electron Transport Homeostasis Lipid Metabolism Liver Male Membrane Potential, Mitochondrial Mitochondria Nucleotides Oxidants Oxidative Stress Permeability Proteolysis Rats Rats, Sprague-Dawley Sulfonamides Terpenes Transcription, Genetic Singh B.K. Tripathi M. Chaudhari B.P. Pandey P.K. Kakkar P. Natural terpenes prevent mitochondrial dysfunction, oxidative stress and release of apoptotic proteins during nimesulide-hepatotoxicity in rats
description	10.1371/journal.pone.0034200
author2	DUKE-NUS MEDICAL SCHOOL
author_facet	DUKE-NUS MEDICAL SCHOOL Singh B.K. Tripathi M. Chaudhari B.P. Pandey P.K. Kakkar P.
format	Article
author	Singh B.K. Tripathi M. Chaudhari B.P. Pandey P.K. Kakkar P.
author_sort	Singh B.K.
title	Natural terpenes prevent mitochondrial dysfunction, oxidative stress and release of apoptotic proteins during nimesulide-hepatotoxicity in rats
title_short	Natural terpenes prevent mitochondrial dysfunction, oxidative stress and release of apoptotic proteins during nimesulide-hepatotoxicity in rats
title_full	Natural terpenes prevent mitochondrial dysfunction, oxidative stress and release of apoptotic proteins during nimesulide-hepatotoxicity in rats
title_fullStr	Natural terpenes prevent mitochondrial dysfunction, oxidative stress and release of apoptotic proteins during nimesulide-hepatotoxicity in rats
title_full_unstemmed	Natural terpenes prevent mitochondrial dysfunction, oxidative stress and release of apoptotic proteins during nimesulide-hepatotoxicity in rats
title_sort	natural terpenes prevent mitochondrial dysfunction, oxidative stress and release of apoptotic proteins during nimesulide-hepatotoxicity in rats
publishDate	2019
url	https://scholarbank.nus.edu.sg/handle/10635/161990
_version_	1781791874464350208

Natural terpenes prevent mitochondrial dysfunction, oxidative stress and release of apoptotic proteins during nimesulide-hepatotoxicity in rats

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