Natural terpenes prevent mitochondrial dysfunction, oxidative stress and release of apoptotic proteins during nimesulide-hepatotoxicity in rats

Natural terpenes prevent mitochondrial dysfunction, oxidative stress and release of apoptotic proteins during nimesulide-hepatotoxicity in rats

10.1371/journal.pone.0034200

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Bibliographic Details
Main Authors:	Singh B.K., Tripathi M., Chaudhari B.P., Pandey P.K., Kakkar P.
Other Authors:	DUKE-NUS MEDICAL SCHOOL
Format:	Article
Published:	2019
Subjects:	8 hydroxyguanine alanine aminotransferase apoptosis inducing factor aspartate aminotransferase bilirubin biological marker camphene caspase 3 caspase 9 copper zinc superoxide dismutase cytochrome c DNA endonuclease G geraniol glutathione glutathione peroxidase glutathione reductase inducible nitric oxide synthase manganese superoxide dismutase messenger RNA mitochondrial nitric oxide synthase neuronal nitric oxide synthase nimesulide reactive nitrogen species reactive oxygen metabolite reduced nicotinamide adenine dinucleotide phosphate silymarin terpene derivative unclassified drug antioxidant apoptosis regulatory protein biological product nucleotide oxidizing agent sulfonamide terpene alanine aminotransferase blood level animal cell animal experiment animal model animal tissue antioxidant activity article aspartate aminotransferase blood level bilirubin blood level body weight cell membrane permeability controlled study disorders of mitochondrial functions DNA damage drug megadose drug structure enzyme activity enzyme inhibition histopathology immunoblotting in vivo study liver toxicity macromolecule male membrane depolarization mitochondrial energy transfer mitochondrion swelling molecular mechanics nonhuman oxidative stress protein expression protein secretion protein synthesis inhibition rat Sprague Dawley rat structure analysis animal cell death cell protection cytology drug effect electron transport genetic transcription homeostasis lipid metabolism liver metabolism mitochondrial membrane potential mitochondrion pathology permeability protein degradation secretion Rattus Animals Antioxidants Apoptosis Regulatory Proteins Biological Agents Caspase 3 Caspase 9 Cell Death Cytoprotection DNA Damage Electron Transport Homeostasis Lipid Metabolism Liver Male Membrane Potential, Mitochondrial Mitochondria Nucleotides Oxidants Oxidative Stress Permeability Proteolysis Rats Rats, Sprague-Dawley Sulfonamides Terpenes Transcription, Genetic
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/161990
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Institution:	National University of Singapore

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