Discovery that theonellasterol a marine sponge sterol is a highly selective FXR antagonist that protects against liver injury in cholestasis

10.1371/journal.pone.0030443

Saved in:

Bibliographic Details
Main Authors:	Renga B., Mencarelli A., D'Amore C., Cipriani S., D'Auria M.V., Sepe V., Chini M.G., Monti M.C., Bifulco G., Zampella A., Fiorucci S.
Other Authors:	NUSHS PROJECT
Format:	Article
Published:	2019
Subjects:	alanine aminotransferase bile acid estrogen receptor glucocorticoid receptor liver protective agent multidrug resistance protein 4 peroxisome proliferator activated receptor progesterone receptor protein LXR protein PXR receptor protein theonellasterol thyroid receptor unclassified drug vitamin D receptor 7 hydroxytheonellasterol 7-hydroxytheonellasterol cell receptor farnesoid X receptor farnesoid X-activated receptor hormone antagonist sterol alanine aminotransferase blood level animal experiment animal model article bioassay BSEP gene cell strain HepG2 controlled study drug effect drug isolation drug mechanism drug receptor binding drug structure extrahepatic bile duct obstruction histopathology in vivo study liver cell liver histology liver injury liver necrosis liver protection microarray analysis molecular docking mouse multidrug resistance associated protein 4 gene nonhuman OSTalpha gene protein expression regulator gene SHP gene transactivation animal aquatic species cell protection chemistry disease model drug antagonism drug development drug screening enzyme specificity feasibility study human injury intrahepatic cholestasis isolation and purification liver pathology sponge (Porifera) Mus Rodentia Theonella swinhoei Animals Aquatic Organisms Cholestasis, Intrahepatic Cytoprotection Disease Models, Animal Drug Discovery Drug Evaluation, Preclinical Feasibility Studies Hep G2 Cells Hormone Antagonists Humans Liver Mice Porifera Receptors, Cytoplasmic and Nuclear Sterols Substrate Specificity
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/162005
Tags:	Add Tag No Tags, Be the first to tag this record!
Institution:	National University of Singapore

id	sg-nus-scholar.10635-162005
record_format	dspace
spelling	sg-nus-scholar.10635-1620052024-11-08T20:46:35Z Discovery that theonellasterol a marine sponge sterol is a highly selective FXR antagonist that protects against liver injury in cholestasis Renga B. Mencarelli A. D'Amore C. Cipriani S. D'Auria M.V. Sepe V. Chini M.G. Monti M.C. Bifulco G. Zampella A. Fiorucci S. NUSHS PROJECT DUKE-NUS MEDICAL SCHOOL alanine aminotransferase bile acid estrogen receptor glucocorticoid receptor liver protective agent multidrug resistance protein 4 peroxisome proliferator activated receptor progesterone receptor protein LXR protein PXR receptor protein theonellasterol thyroid receptor unclassified drug vitamin D receptor 7 hydroxytheonellasterol 7-hydroxytheonellasterol cell receptor farnesoid X receptor farnesoid X-activated receptor hormone antagonist sterol alanine aminotransferase blood level animal experiment animal model article bioassay BSEP gene cell strain HepG2 controlled study drug effect drug isolation drug mechanism drug receptor binding drug structure extrahepatic bile duct obstruction histopathology in vivo study liver cell liver histology liver injury liver necrosis liver protection microarray analysis molecular docking mouse multidrug resistance associated protein 4 gene nonhuman OSTalpha gene protein expression regulator gene SHP gene transactivation animal aquatic species cell protection chemistry disease model drug antagonism drug development drug screening enzyme specificity feasibility study human injury intrahepatic cholestasis isolation and purification liver pathology sponge (Porifera) Mus Rodentia Theonella swinhoei Animals Aquatic Organisms Cholestasis, Intrahepatic Cytoprotection Disease Models, Animal Drug Discovery Drug Evaluation, Preclinical Feasibility Studies Hep G2 Cells Hormone Antagonists Humans Liver Mice Porifera Receptors, Cytoplasmic and Nuclear Sterols Substrate Specificity 10.1371/journal.pone.0030443 PLoS ONE 7 1 e30443 2019-11-11T06:42:59Z 2019-11-11T06:42:59Z 2012 Article Renga B., Mencarelli A., D'Amore C., Cipriani S., D'Auria M.V., Sepe V., Chini M.G., Monti M.C., Bifulco G., Zampella A., Fiorucci S. (2012). Discovery that theonellasterol a marine sponge sterol is a highly selective FXR antagonist that protects against liver injury in cholestasis. PLoS ONE 7 (1) : e30443. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0030443 19326203 https://scholarbank.nus.edu.sg/handle/10635/162005 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Unpaywall 20191101
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	alanine aminotransferase bile acid estrogen receptor glucocorticoid receptor liver protective agent multidrug resistance protein 4 peroxisome proliferator activated receptor progesterone receptor protein LXR protein PXR receptor protein theonellasterol thyroid receptor unclassified drug vitamin D receptor 7 hydroxytheonellasterol 7-hydroxytheonellasterol cell receptor farnesoid X receptor farnesoid X-activated receptor hormone antagonist sterol alanine aminotransferase blood level animal experiment animal model article bioassay BSEP gene cell strain HepG2 controlled study drug effect drug isolation drug mechanism drug receptor binding drug structure extrahepatic bile duct obstruction histopathology in vivo study liver cell liver histology liver injury liver necrosis liver protection microarray analysis molecular docking mouse multidrug resistance associated protein 4 gene nonhuman OSTalpha gene protein expression regulator gene SHP gene transactivation animal aquatic species cell protection chemistry disease model drug antagonism drug development drug screening enzyme specificity feasibility study human injury intrahepatic cholestasis isolation and purification liver pathology sponge (Porifera) Mus Rodentia Theonella swinhoei Animals Aquatic Organisms Cholestasis, Intrahepatic Cytoprotection Disease Models, Animal Drug Discovery Drug Evaluation, Preclinical Feasibility Studies Hep G2 Cells Hormone Antagonists Humans Liver Mice Porifera Receptors, Cytoplasmic and Nuclear Sterols Substrate Specificity
spellingShingle	alanine aminotransferase bile acid estrogen receptor glucocorticoid receptor liver protective agent multidrug resistance protein 4 peroxisome proliferator activated receptor progesterone receptor protein LXR protein PXR receptor protein theonellasterol thyroid receptor unclassified drug vitamin D receptor 7 hydroxytheonellasterol 7-hydroxytheonellasterol cell receptor farnesoid X receptor farnesoid X-activated receptor hormone antagonist sterol alanine aminotransferase blood level animal experiment animal model article bioassay BSEP gene cell strain HepG2 controlled study drug effect drug isolation drug mechanism drug receptor binding drug structure extrahepatic bile duct obstruction histopathology in vivo study liver cell liver histology liver injury liver necrosis liver protection microarray analysis molecular docking mouse multidrug resistance associated protein 4 gene nonhuman OSTalpha gene protein expression regulator gene SHP gene transactivation animal aquatic species cell protection chemistry disease model drug antagonism drug development drug screening enzyme specificity feasibility study human injury intrahepatic cholestasis isolation and purification liver pathology sponge (Porifera) Mus Rodentia Theonella swinhoei Animals Aquatic Organisms Cholestasis, Intrahepatic Cytoprotection Disease Models, Animal Drug Discovery Drug Evaluation, Preclinical Feasibility Studies Hep G2 Cells Hormone Antagonists Humans Liver Mice Porifera Receptors, Cytoplasmic and Nuclear Sterols Substrate Specificity Renga B. Mencarelli A. D'Amore C. Cipriani S. D'Auria M.V. Sepe V. Chini M.G. Monti M.C. Bifulco G. Zampella A. Fiorucci S. Discovery that theonellasterol a marine sponge sterol is a highly selective FXR antagonist that protects against liver injury in cholestasis
description	10.1371/journal.pone.0030443
author2	NUSHS PROJECT
author_facet	NUSHS PROJECT Renga B. Mencarelli A. D'Amore C. Cipriani S. D'Auria M.V. Sepe V. Chini M.G. Monti M.C. Bifulco G. Zampella A. Fiorucci S.
format	Article
author	Renga B. Mencarelli A. D'Amore C. Cipriani S. D'Auria M.V. Sepe V. Chini M.G. Monti M.C. Bifulco G. Zampella A. Fiorucci S.
author_sort	Renga B.
title	Discovery that theonellasterol a marine sponge sterol is a highly selective FXR antagonist that protects against liver injury in cholestasis
title_short	Discovery that theonellasterol a marine sponge sterol is a highly selective FXR antagonist that protects against liver injury in cholestasis
title_full	Discovery that theonellasterol a marine sponge sterol is a highly selective FXR antagonist that protects against liver injury in cholestasis
title_fullStr	Discovery that theonellasterol a marine sponge sterol is a highly selective FXR antagonist that protects against liver injury in cholestasis
title_full_unstemmed	Discovery that theonellasterol a marine sponge sterol is a highly selective FXR antagonist that protects against liver injury in cholestasis
title_sort	discovery that theonellasterol a marine sponge sterol is a highly selective fxr antagonist that protects against liver injury in cholestasis
publishDate	2019
url	https://scholarbank.nus.edu.sg/handle/10635/162005
_version_	1821187590390284288

Discovery that theonellasterol a marine sponge sterol is a highly selective FXR antagonist that protects against liver injury in cholestasis

Similar Items