CYP5122A1, a novel cytochrome P450 is essential for survival of Leishmania donovani
10.1371/journal.pone.0025273
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sg-nus-scholar.10635-1620312020-11-18T02:03:45Z CYP5122A1, a novel cytochrome P450 is essential for survival of Leishmania donovani Verma S. Mehta A. Shaha C. DUKE-NUS MEDICAL SCHOOL amphotericin B antimony calcium ion cytochrome P450 cytochrome P450 5122A1 ergosterol miltefosine neomycin unclassified drug adenosine triphosphate cytochrome P450 protozoal protein reactive oxygen metabolite allele article controlled study endoplasmic reticulum enzyme activity enzyme localization glycosome hamster in vitro study in vivo study Leishmania donovani macrophage mass fragmentography membrane potential mitochondrion nonhuman parasite survival phenotype promastigote protein expression wild type animal classification drug effect genetics genome immunohistochemistry metabolism parasitology pathogenicity phylogeny polyacrylamide gel electrophoresis Syrian hamster visceral leishmaniasis Western blotting Cricetinae Leishmania donovani Adenosine Triphosphate Animals Blotting, Western Cricetinae Cytochrome P-450 Enzyme System Electrophoresis, Polyacrylamide Gel Ergosterol Genome, Protozoan Immunohistochemistry Leishmania donovani Leishmaniasis, Visceral Mesocricetus Mitochondria Phylogeny Protozoan Proteins Reactive Oxygen Species 10.1371/journal.pone.0025273 PLoS ONE 6 9 e25273 2019-11-11T08:37:46Z 2019-11-11T08:37:46Z 2011 Article Verma S., Mehta A., Shaha C. (2011). CYP5122A1, a novel cytochrome P450 is essential for survival of Leishmania donovani. PLoS ONE 6 (9) : e25273. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0025273 19326203 https://scholarbank.nus.edu.sg/handle/10635/162031 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Unpaywall 20191101 |
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amphotericin B antimony calcium ion cytochrome P450 cytochrome P450 5122A1 ergosterol miltefosine neomycin unclassified drug adenosine triphosphate cytochrome P450 protozoal protein reactive oxygen metabolite allele article controlled study endoplasmic reticulum enzyme activity enzyme localization glycosome hamster in vitro study in vivo study Leishmania donovani macrophage mass fragmentography membrane potential mitochondrion nonhuman parasite survival phenotype promastigote protein expression wild type animal classification drug effect genetics genome immunohistochemistry metabolism parasitology pathogenicity phylogeny polyacrylamide gel electrophoresis Syrian hamster visceral leishmaniasis Western blotting Cricetinae Leishmania donovani Adenosine Triphosphate Animals Blotting, Western Cricetinae Cytochrome P-450 Enzyme System Electrophoresis, Polyacrylamide Gel Ergosterol Genome, Protozoan Immunohistochemistry Leishmania donovani Leishmaniasis, Visceral Mesocricetus Mitochondria Phylogeny Protozoan Proteins Reactive Oxygen Species |
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amphotericin B antimony calcium ion cytochrome P450 cytochrome P450 5122A1 ergosterol miltefosine neomycin unclassified drug adenosine triphosphate cytochrome P450 protozoal protein reactive oxygen metabolite allele article controlled study endoplasmic reticulum enzyme activity enzyme localization glycosome hamster in vitro study in vivo study Leishmania donovani macrophage mass fragmentography membrane potential mitochondrion nonhuman parasite survival phenotype promastigote protein expression wild type animal classification drug effect genetics genome immunohistochemistry metabolism parasitology pathogenicity phylogeny polyacrylamide gel electrophoresis Syrian hamster visceral leishmaniasis Western blotting Cricetinae Leishmania donovani Adenosine Triphosphate Animals Blotting, Western Cricetinae Cytochrome P-450 Enzyme System Electrophoresis, Polyacrylamide Gel Ergosterol Genome, Protozoan Immunohistochemistry Leishmania donovani Leishmaniasis, Visceral Mesocricetus Mitochondria Phylogeny Protozoan Proteins Reactive Oxygen Species Verma S. Mehta A. Shaha C. CYP5122A1, a novel cytochrome P450 is essential for survival of Leishmania donovani |
| description |
10.1371/journal.pone.0025273 |
| author2 |
DUKE-NUS MEDICAL SCHOOL |
| author_facet |
DUKE-NUS MEDICAL SCHOOL Verma S. Mehta A. Shaha C. |
| format |
Article |
| author |
Verma S. Mehta A. Shaha C. |
| author_sort |
Verma S. |
| title |
CYP5122A1, a novel cytochrome P450 is essential for survival of Leishmania donovani |
| title_short |
CYP5122A1, a novel cytochrome P450 is essential for survival of Leishmania donovani |
| title_full |
CYP5122A1, a novel cytochrome P450 is essential for survival of Leishmania donovani |
| title_fullStr |
CYP5122A1, a novel cytochrome P450 is essential for survival of Leishmania donovani |
| title_full_unstemmed |
CYP5122A1, a novel cytochrome P450 is essential for survival of Leishmania donovani |
| title_sort |
cyp5122a1, a novel cytochrome p450 is essential for survival of leishmania donovani |
| publishDate |
2019 |
| url |
https://scholarbank.nus.edu.sg/handle/10635/162031 |
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1686108560238313472 |