CYP5122A1, a novel cytochrome P450 is essential for survival of Leishmania donovani

• Main Authors: Verma S., Mehta A., Shaha C.
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: 2019
• Subjects: amphotericin B; antimony; calcium ion; cytochrome P450; cytochrome P450 5122A1; ergosterol; miltefosine; neomycin; unclassified drug; adenosine triphosphate; protozoal protein; reactive oxygen metabolite; allele; article; controlled study; endoplasmic reticulum; enzyme activity; enzyme localization; glycosome; hamster; in vitro study; in vivo study; Leishmania donovani; macrophage; mass fragmentography; membrane potential; mitochondrion; nonhuman; parasite survival; phenotype; promastigote; protein expression; wild type; animal; classification; drug effect; genetics; genome; immunohistochemistry; metabolism; parasitology; pathogenicity; phylogeny; polyacrylamide gel electrophoresis; Syrian hamster; visceral leishmaniasis; Western blotting; Cricetinae; Adenosine Triphosphate; Animals; Blotting, Western; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Ergosterol; Genome, Protozoan; Immunohistochemistry; Leishmaniasis, Visceral; Mesocricetus; Mitochondria; Phylogeny; Protozoan Proteins; Reactive Oxygen Species
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/162031
• Institution: National University of Singapore

10.1371/journal.pone.0025273