Trans-Ethnic Fine-Mapping of Lipid Loci Identifies Population-Specific Signals and Allelic Heterogeneity That Increases the Trait Variance Explained

Trans-Ethnic Fine-Mapping of Lipid Loci Identifies Population-Specific Signals and Allelic Heterogeneity That Increases the Trait Variance Explained

10.1371/journal.pgen.1003379

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Bibliographic Details
Main Authors:	Wu Y., Waite L.L., Jackson A.U., Sheu W.-H.H., Buyske S., Absher D., Arnett D.K., Boerwinkle E., Bonnycastle L.L., Carty C.L., Cheng I., Cochran B., Croteau-Chonka D.C., Dumitrescu L., Eaton C.B., Franceschini N., Guo X., Henderson B.E., Hindorff L.A., Kim E., Kinnunen L., Komulainen P., Lee W.-J., Le Marchand L., Lin Y., Lindström J., Lingaas-Holmen O., Mitchell S.L., Narisu N., Robinson J.G., Schumacher F., Stančáková A., Sundvall J., Sung Y.-J., Swift A.J., Wang W.-C., Wilkens L., Wilsgaard T., Young A.M., Adair L.S., Ballantyne C.M., Bůžková P., Chakravarti A., Collins F.S., Duggan D., Feranil A.B., Ho L.-T., Hung Y.-J., Hunt S.C., Hveem K., Juang J.-M.J., Kesäniemi A.Y., Kuusisto J., Laakso M., Lakka T.A., Lee I.-T., Leppert M.F., Matise T.C., Moilanen L., Njølstad I., Peters U., Quertermous T., Rauramaa R., Rotter J.I., Saramies J., Tuomilehto J., Uusitupa M., Wang T.-D., Boehnke M., Haiman C.A., Chen Y.-D.I., Kooperberg C., Assimes T.L., Crawford D.C., Hsiung C.A., North K.E., Mohlke K.L.
Format:	Article
Published:	Public Library of Science 2020
Subjects:	high density lipoprotein cholesterol lipid low density lipoprotein cholesterol triacylglycerol ABCA1 gene ABO gene African American allele APOA5 gene article Asian controlled study Europe female GCKR gene gene locus gene mapping genetic association genetic heterogeneity genetic trait genotype human Lcat gene lipid blood level male PCSK9 gene phenotype population genetics PPP1R3B gene single nucleotide polymorphism African Americans Apolipoproteins A Cholesterol, HDL Cholesterol, LDL European Continental Ancestry Group Genome-Wide Association Study Humans Lipoproteins, HDL Lipoproteins, LDL Proprotein Convertases Serine Endopeptidases Triglycerides
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/165404
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Institution:	National University of Singapore

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Summary:	10.1371/journal.pgen.1003379