Trans-Ethnic Fine-Mapping of Lipid Loci Identifies Population-Specific Signals and Allelic Heterogeneity That Increases the Trait Variance Explained

• Main Authors: Wu Y., Waite L.L., Jackson A.U., Sheu W.-H.H., Buyske S., Absher D., Arnett D.K., Boerwinkle E., Bonnycastle L.L., Carty C.L., Cheng I., Cochran B., Croteau-Chonka D.C., Dumitrescu L., Eaton C.B., Franceschini N., Guo X., Henderson B.E., Hindorff L.A., Kim E., Kinnunen L., Komulainen P., Lee W.-J., Le Marchand L., Lin Y., Lindström J., Lingaas-Holmen O., Mitchell S.L., Narisu N., Robinson J.G., Schumacher F., Stančáková A., Sundvall J., Sung Y.-J., Swift A.J., Wang W.-C., Wilkens L., Wilsgaard T., Young A.M., Adair L.S., Ballantyne C.M., Bůžková P., Chakravarti A., Collins F.S., Duggan D., Feranil A.B., Ho L.-T., Hung Y.-J., Hunt S.C., Hveem K., Juang J.-M.J., Kesäniemi A.Y., Kuusisto J., Laakso M., Lakka T.A., Lee I.-T., Leppert M.F., Matise T.C., Moilanen L., Njølstad I., Peters U., Quertermous T., Rauramaa R., Rotter J.I., Saramies J., Tuomilehto J., Uusitupa M., Wang T.-D., Boehnke M., Haiman C.A., Chen Y.-D.I., Kooperberg C., Assimes T.L., Crawford D.C., Hsiung C.A., North K.E., Mohlke K.L.
• Format: Article
• Published: Public Library of Science 2020
• Subjects: high density lipoprotein cholesterol; lipid; low density lipoprotein cholesterol; triacylglycerol; ABCA1 gene; ABO gene; African American; allele; APOA5 gene; article; Asian; controlled study; Europe; female; GCKR gene; gene locus; gene mapping; genetic association; genetic heterogeneity; genetic trait; genotype; human; Lcat gene; lipid blood level; male; PCSK9 gene; phenotype; population genetics; PPP1R3B gene; single nucleotide polymorphism; African Americans; Apolipoproteins A; Cholesterol, HDL; Cholesterol, LDL; European Continental Ancestry Group; Genome-Wide Association Study; Humans; Lipoproteins, HDL; Lipoproteins, LDL; Proprotein Convertases; Serine Endopeptidases; Triglycerides
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/165404
• Institution: National University of Singapore

10.1371/journal.pgen.1003379