Trans-Ethnic Fine-Mapping of Lipid Loci Identifies Population-Specific Signals and Allelic Heterogeneity That Increases the Trait Variance Explained

10.1371/journal.pgen.1003379

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Main Authors:	Wu Y., Waite L.L., Jackson A.U., Sheu W.-H.H., Buyske S., Absher D., Arnett D.K., Boerwinkle E., Bonnycastle L.L., Carty C.L., Cheng I., Cochran B., Croteau-Chonka D.C., Dumitrescu L., Eaton C.B., Franceschini N., Guo X., Henderson B.E., Hindorff L.A., Kim E., Kinnunen L., Komulainen P., Lee W.-J., Le Marchand L., Lin Y., Lindström J., Lingaas-Holmen O., Mitchell S.L., Narisu N., Robinson J.G., Schumacher F., Stančáková A., Sundvall J., Sung Y.-J., Swift A.J., Wang W.-C., Wilkens L., Wilsgaard T., Young A.M., Adair L.S., Ballantyne C.M., Bůžková P., Chakravarti A., Collins F.S., Duggan D., Feranil A.B., Ho L.-T., Hung Y.-J., Hunt S.C., Hveem K., Juang J.-M.J., Kesäniemi A.Y., Kuusisto J., Laakso M., Lakka T.A., Lee I.-T., Leppert M.F., Matise T.C., Moilanen L., Njølstad I., Peters U., Quertermous T., Rauramaa R., Rotter J.I., Saramies J., Tuomilehto J., Uusitupa M., Wang T.-D., Boehnke M., Haiman C.A., Chen Y.-D.I., Kooperberg C., Assimes T.L., Crawford D.C., Hsiung C.A., North K.E., Mohlke K.L.
Format:	Article
Published:	Public Library of Science 2020
Subjects:	high density lipoprotein cholesterol lipid low density lipoprotein cholesterol triacylglycerol ABCA1 gene ABO gene African American allele APOA5 gene article Asian controlled study Europe female GCKR gene gene locus gene mapping genetic association genetic heterogeneity genetic trait genotype human Lcat gene lipid blood level male PCSK9 gene phenotype population genetics PPP1R3B gene single nucleotide polymorphism African Americans Apolipoproteins A Cholesterol, HDL Cholesterol, LDL European Continental Ancestry Group Genome-Wide Association Study Humans Lipoproteins, HDL Lipoproteins, LDL Proprotein Convertases Serine Endopeptidases Triglycerides
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/165404
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spelling	sg-nus-scholar.10635-1654042023-10-31T09:04:36Z Trans-Ethnic Fine-Mapping of Lipid Loci Identifies Population-Specific Signals and Allelic Heterogeneity That Increases the Trait Variance Explained Wu Y. Waite L.L. Jackson A.U. Sheu W.-H.H. Buyske S. Absher D. Arnett D.K. Boerwinkle E. Bonnycastle L.L. Carty C.L. Cheng I. Cochran B. Croteau-Chonka D.C. Dumitrescu L. Eaton C.B. Franceschini N. Guo X. Henderson B.E. Hindorff L.A. Kim E. Kinnunen L. Komulainen P. Lee W.-J. Le Marchand L. Lin Y. Lindström J. Lingaas-Holmen O. Mitchell S.L. Narisu N. Robinson J.G. Schumacher F. Stančáková A. Sundvall J. Sung Y.-J. Swift A.J. Wang W.-C. Wilkens L. Wilsgaard T. Young A.M. Adair L.S. Ballantyne C.M. Bůžková P. Chakravarti A. Collins F.S. Duggan D. Feranil A.B. Ho L.-T. Hung Y.-J. Hunt S.C. Hveem K. Juang J.-M.J. Kesäniemi A.Y. Kuusisto J. Laakso M. Lakka T.A. Lee I.-T. Leppert M.F. Matise T.C. Moilanen L. Njølstad I. Peters U. Quertermous T. Rauramaa R. Rotter J.I. Saramies J. Tuomilehto J. Uusitupa M. Wang T.-D. Boehnke M. Haiman C.A. Chen Y.-D.I. Kooperberg C. Assimes T.L. Crawford D.C. Hsiung C.A. North K.E. Mohlke K.L. high density lipoprotein cholesterol lipid low density lipoprotein cholesterol triacylglycerol ABCA1 gene ABO gene African American allele APOA5 gene article Asian controlled study Europe female GCKR gene gene locus gene mapping genetic association genetic heterogeneity genetic trait genotype human Lcat gene lipid blood level male PCSK9 gene phenotype population genetics PPP1R3B gene single nucleotide polymorphism African Americans Apolipoproteins A Cholesterol, HDL Cholesterol, LDL European Continental Ancestry Group Genome-Wide Association Study Humans Lipoproteins, HDL Lipoproteins, LDL Proprotein Convertases Serine Endopeptidases Triglycerides 10.1371/journal.pgen.1003379 PLoS Genetics 9 3 e1003379 2020-03-13T05:25:43Z 2020-03-13T05:25:43Z 2013 Article Wu Y., Waite L.L., Jackson A.U., Sheu W.-H.H., Buyske S., Absher D., Arnett D.K., Boerwinkle E., Bonnycastle L.L., Carty C.L., Cheng I., Cochran B., Croteau-Chonka D.C., Dumitrescu L., Eaton C.B., Franceschini N., Guo X., Henderson B.E., Hindorff L.A., Kim E., Kinnunen L., Komulainen P., Lee W.-J., Le Marchand L., Lin Y., Lindström J., Lingaas-Holmen O., Mitchell S.L., Narisu N., Robinson J.G., Schumacher F., Stančáková A., Sundvall J., Sung Y.-J., Swift A.J., Wang W.-C., Wilkens L., Wilsgaard T., Young A.M., Adair L.S., Ballantyne C.M., Bůžková P., Chakravarti A., Collins F.S., Duggan D., Feranil A.B., Ho L.-T., Hung Y.-J., Hunt S.C., Hveem K., Juang J.-M.J., Kesäniemi A.Y., Kuusisto J., Laakso M., Lakka T.A., Lee I.-T., Leppert M.F., Matise T.C., Moilanen L., Njølstad I., Peters U., Quertermous T., Rauramaa R., Rotter J.I., Saramies J., Tuomilehto J., Uusitupa M., Wang T.-D., Boehnke M., Haiman C.A., Chen Y.-D.I., Kooperberg C., Assimes T.L., Crawford D.C., Hsiung C.A., North K.E., Mohlke K.L. (2013). Trans-Ethnic Fine-Mapping of Lipid Loci Identifies Population-Specific Signals and Allelic Heterogeneity That Increases the Trait Variance Explained. PLoS Genetics 9 (3) : e1003379. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pgen.1003379 15537390 https://scholarbank.nus.edu.sg/handle/10635/165404 Public Library of Science Unpaywall 20200320
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	high density lipoprotein cholesterol lipid low density lipoprotein cholesterol triacylglycerol ABCA1 gene ABO gene African American allele APOA5 gene article Asian controlled study Europe female GCKR gene gene locus gene mapping genetic association genetic heterogeneity genetic trait genotype human Lcat gene lipid blood level male PCSK9 gene phenotype population genetics PPP1R3B gene single nucleotide polymorphism African Americans Apolipoproteins A Cholesterol, HDL Cholesterol, LDL European Continental Ancestry Group Genome-Wide Association Study Humans Lipoproteins, HDL Lipoproteins, LDL Proprotein Convertases Serine Endopeptidases Triglycerides
spellingShingle	high density lipoprotein cholesterol lipid low density lipoprotein cholesterol triacylglycerol ABCA1 gene ABO gene African American allele APOA5 gene article Asian controlled study Europe female GCKR gene gene locus gene mapping genetic association genetic heterogeneity genetic trait genotype human Lcat gene lipid blood level male PCSK9 gene phenotype population genetics PPP1R3B gene single nucleotide polymorphism African Americans Apolipoproteins A Cholesterol, HDL Cholesterol, LDL European Continental Ancestry Group Genome-Wide Association Study Humans Lipoproteins, HDL Lipoproteins, LDL Proprotein Convertases Serine Endopeptidases Triglycerides Wu Y. Waite L.L. Jackson A.U. Sheu W.-H.H. Buyske S. Absher D. Arnett D.K. Boerwinkle E. Bonnycastle L.L. Carty C.L. Cheng I. Cochran B. Croteau-Chonka D.C. Dumitrescu L. Eaton C.B. Franceschini N. Guo X. Henderson B.E. Hindorff L.A. Kim E. Kinnunen L. Komulainen P. Lee W.-J. Le Marchand L. Lin Y. Lindström J. Lingaas-Holmen O. Mitchell S.L. Narisu N. Robinson J.G. Schumacher F. Stančáková A. Sundvall J. Sung Y.-J. Swift A.J. Wang W.-C. Wilkens L. Wilsgaard T. Young A.M. Adair L.S. Ballantyne C.M. Bůžková P. Chakravarti A. Collins F.S. Duggan D. Feranil A.B. Ho L.-T. Hung Y.-J. Hunt S.C. Hveem K. Juang J.-M.J. Kesäniemi A.Y. Kuusisto J. Laakso M. Lakka T.A. Lee I.-T. Leppert M.F. Matise T.C. Moilanen L. Njølstad I. Peters U. Quertermous T. Rauramaa R. Rotter J.I. Saramies J. Tuomilehto J. Uusitupa M. Wang T.-D. Boehnke M. Haiman C.A. Chen Y.-D.I. Kooperberg C. Assimes T.L. Crawford D.C. Hsiung C.A. North K.E. Mohlke K.L. Trans-Ethnic Fine-Mapping of Lipid Loci Identifies Population-Specific Signals and Allelic Heterogeneity That Increases the Trait Variance Explained
description	10.1371/journal.pgen.1003379
format	Article
author	Wu Y. Waite L.L. Jackson A.U. Sheu W.-H.H. Buyske S. Absher D. Arnett D.K. Boerwinkle E. Bonnycastle L.L. Carty C.L. Cheng I. Cochran B. Croteau-Chonka D.C. Dumitrescu L. Eaton C.B. Franceschini N. Guo X. Henderson B.E. Hindorff L.A. Kim E. Kinnunen L. Komulainen P. Lee W.-J. Le Marchand L. Lin Y. Lindström J. Lingaas-Holmen O. Mitchell S.L. Narisu N. Robinson J.G. Schumacher F. Stančáková A. Sundvall J. Sung Y.-J. Swift A.J. Wang W.-C. Wilkens L. Wilsgaard T. Young A.M. Adair L.S. Ballantyne C.M. Bůžková P. Chakravarti A. Collins F.S. Duggan D. Feranil A.B. Ho L.-T. Hung Y.-J. Hunt S.C. Hveem K. Juang J.-M.J. Kesäniemi A.Y. Kuusisto J. Laakso M. Lakka T.A. Lee I.-T. Leppert M.F. Matise T.C. Moilanen L. Njølstad I. Peters U. Quertermous T. Rauramaa R. Rotter J.I. Saramies J. Tuomilehto J. Uusitupa M. Wang T.-D. Boehnke M. Haiman C.A. Chen Y.-D.I. Kooperberg C. Assimes T.L. Crawford D.C. Hsiung C.A. North K.E. Mohlke K.L.
author_facet	Wu Y. Waite L.L. Jackson A.U. Sheu W.-H.H. Buyske S. Absher D. Arnett D.K. Boerwinkle E. Bonnycastle L.L. Carty C.L. Cheng I. Cochran B. Croteau-Chonka D.C. Dumitrescu L. Eaton C.B. Franceschini N. Guo X. Henderson B.E. Hindorff L.A. Kim E. Kinnunen L. Komulainen P. Lee W.-J. Le Marchand L. Lin Y. Lindström J. Lingaas-Holmen O. Mitchell S.L. Narisu N. Robinson J.G. Schumacher F. Stančáková A. Sundvall J. Sung Y.-J. Swift A.J. Wang W.-C. Wilkens L. Wilsgaard T. Young A.M. Adair L.S. Ballantyne C.M. Bůžková P. Chakravarti A. Collins F.S. Duggan D. Feranil A.B. Ho L.-T. Hung Y.-J. Hunt S.C. Hveem K. Juang J.-M.J. Kesäniemi A.Y. Kuusisto J. Laakso M. Lakka T.A. Lee I.-T. Leppert M.F. Matise T.C. Moilanen L. Njølstad I. Peters U. Quertermous T. Rauramaa R. Rotter J.I. Saramies J. Tuomilehto J. Uusitupa M. Wang T.-D. Boehnke M. Haiman C.A. Chen Y.-D.I. Kooperberg C. Assimes T.L. Crawford D.C. Hsiung C.A. North K.E. Mohlke K.L.
author_sort	Wu Y.
title	Trans-Ethnic Fine-Mapping of Lipid Loci Identifies Population-Specific Signals and Allelic Heterogeneity That Increases the Trait Variance Explained
title_short	Trans-Ethnic Fine-Mapping of Lipid Loci Identifies Population-Specific Signals and Allelic Heterogeneity That Increases the Trait Variance Explained
title_full	Trans-Ethnic Fine-Mapping of Lipid Loci Identifies Population-Specific Signals and Allelic Heterogeneity That Increases the Trait Variance Explained
title_fullStr	Trans-Ethnic Fine-Mapping of Lipid Loci Identifies Population-Specific Signals and Allelic Heterogeneity That Increases the Trait Variance Explained
title_full_unstemmed	Trans-Ethnic Fine-Mapping of Lipid Loci Identifies Population-Specific Signals and Allelic Heterogeneity That Increases the Trait Variance Explained
title_sort	trans-ethnic fine-mapping of lipid loci identifies population-specific signals and allelic heterogeneity that increases the trait variance explained
publisher	Public Library of Science
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/165404
_version_	1781791934316019712

Trans-Ethnic Fine-Mapping of Lipid Loci Identifies Population-Specific Signals and Allelic Heterogeneity That Increases the Trait Variance Explained

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