Crystal structure and functional analysis of the SARS-coronavirus RNA cap 2′-o-methyltransferase nsp10/nsp16 complex

Crystal structure and functional analysis of the SARS-coronavirus RNA cap 2′-o-methyltransferase nsp10/nsp16 complex

10.1371/journal.ppat.1002059

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Bibliographic Details
Main Authors:	Decroly E., Debarnot C., Ferron F., Bouvet M., Coutard B., Imbert I., Gluais L., Papageorgiou N., Sharff A., Bricogne G., Ortiz-Lombardia M., Lescar J., Canard B.
Other Authors:	DUKE-NUS MEDICAL SCHOOL
Format:	Article
Published:	Public Library of Science 2020
Subjects:	methyltransferase RNA s adenosylmethionine SARS coronavirus RNA Cap 2' o methyltransferase nsp10 nsp16 complex sinefungin unclassified drug adenosine capped RNA drug derivative magnesium Nsp10 protein, SARS virus Nsp16 protein, SARS virus rna 2' o methyltransferase RNA 2'-O-methyltransferase virus protein virus RNA article binding site catalysis crystal structure crystallization enzyme activity nonhuman protein analysis protein binding protein protein interaction protein structure RNA binding RNA capping SARS coronavirus chemistry genetics metabolism mutation plasmid RNA viruses Adenosine Crystallization Magnesium Methyltransferases Mutation Plasmids Protein Binding RNA Caps RNA, Viral S-Adenosylmethionine SARS Virus Viral Nonstructural Proteins
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/165412
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Institution:	National University of Singapore

Description
Summary:	10.1371/journal.ppat.1002059