Crystal structure and functional analysis of the SARS-coronavirus RNA cap 2′-o-methyltransferase nsp10/nsp16 complex

10.1371/journal.ppat.1002059

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Main Authors: Decroly E., Debarnot C., Ferron F., Bouvet M., Coutard B., Imbert I., Gluais L., Papageorgiou N., Sharff A., Bricogne G., Ortiz-Lombardia M., Lescar J., Canard B.
Other Authors: DUKE-NUS MEDICAL SCHOOL
Format: Article
Published: Public Library of Science 2020
Subjects:
RNA
Online Access:https://scholarbank.nus.edu.sg/handle/10635/165412
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spelling sg-nus-scholar.10635-1654122023-11-01T07:32:24Z Crystal structure and functional analysis of the SARS-coronavirus RNA cap 2′-o-methyltransferase nsp10/nsp16 complex Decroly E. Debarnot C. Ferron F. Bouvet M. Coutard B. Imbert I. Gluais L. Papageorgiou N. Sharff A. Bricogne G. Ortiz-Lombardia M. Lescar J. Canard B. DUKE-NUS MEDICAL SCHOOL methyltransferase RNA s adenosylmethionine SARS coronavirus RNA Cap 2' o methyltransferase nsp10 nsp16 complex sinefungin unclassified drug adenosine capped RNA drug derivative magnesium Nsp10 protein, SARS virus Nsp16 protein, SARS virus rna 2' o methyltransferase RNA 2'-O-methyltransferase virus protein virus RNA article binding site catalysis crystal structure crystallization enzyme activity nonhuman protein analysis protein binding protein protein interaction protein structure RNA binding RNA capping SARS coronavirus chemistry genetics metabolism mutation plasmid RNA viruses SARS coronavirus Adenosine Crystallization Magnesium Methyltransferases Mutation Plasmids Protein Binding RNA Caps RNA, Viral S-Adenosylmethionine SARS Virus Viral Nonstructural Proteins 10.1371/journal.ppat.1002059 PLoS Pathogens 7 5 e1002059 2020-03-13T05:26:34Z 2020-03-13T05:26:34Z 2011 Article Decroly E., Debarnot C., Ferron F., Bouvet M., Coutard B., Imbert I., Gluais L., Papageorgiou N., Sharff A., Bricogne G., Ortiz-Lombardia M., Lescar J., Canard B. (2011). Crystal structure and functional analysis of the SARS-coronavirus RNA cap 2′-o-methyltransferase nsp10/nsp16 complex. PLoS Pathogens 7 (5) : e1002059. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.ppat.1002059 15537366 https://scholarbank.nus.edu.sg/handle/10635/165412 Public Library of Science Unpaywall 20200320
institution National University of Singapore
building NUS Library
continent Asia
country Singapore
Singapore
content_provider NUS Library
collection ScholarBank@NUS
topic methyltransferase
RNA
s adenosylmethionine
SARS coronavirus RNA Cap 2' o methyltransferase nsp10 nsp16 complex
sinefungin
unclassified drug
adenosine
capped RNA
drug derivative
magnesium
Nsp10 protein, SARS virus
Nsp16 protein, SARS virus
rna 2' o methyltransferase
RNA 2'-O-methyltransferase
virus protein
virus RNA
article
binding site
catalysis
crystal structure
crystallization
enzyme activity
nonhuman
protein analysis
protein binding
protein protein interaction
protein structure
RNA binding
RNA capping
SARS coronavirus
chemistry
genetics
metabolism
mutation
plasmid
RNA viruses
SARS coronavirus
Adenosine
Crystallization
Magnesium
Methyltransferases
Mutation
Plasmids
Protein Binding
RNA Caps
RNA, Viral
S-Adenosylmethionine
SARS Virus
Viral Nonstructural Proteins
spellingShingle methyltransferase
RNA
s adenosylmethionine
SARS coronavirus RNA Cap 2' o methyltransferase nsp10 nsp16 complex
sinefungin
unclassified drug
adenosine
capped RNA
drug derivative
magnesium
Nsp10 protein, SARS virus
Nsp16 protein, SARS virus
rna 2' o methyltransferase
RNA 2'-O-methyltransferase
virus protein
virus RNA
article
binding site
catalysis
crystal structure
crystallization
enzyme activity
nonhuman
protein analysis
protein binding
protein protein interaction
protein structure
RNA binding
RNA capping
SARS coronavirus
chemistry
genetics
metabolism
mutation
plasmid
RNA viruses
SARS coronavirus
Adenosine
Crystallization
Magnesium
Methyltransferases
Mutation
Plasmids
Protein Binding
RNA Caps
RNA, Viral
S-Adenosylmethionine
SARS Virus
Viral Nonstructural Proteins
Decroly E.
Debarnot C.
Ferron F.
Bouvet M.
Coutard B.
Imbert I.
Gluais L.
Papageorgiou N.
Sharff A.
Bricogne G.
Ortiz-Lombardia M.
Lescar J.
Canard B.
Crystal structure and functional analysis of the SARS-coronavirus RNA cap 2′-o-methyltransferase nsp10/nsp16 complex
description 10.1371/journal.ppat.1002059
author2 DUKE-NUS MEDICAL SCHOOL
author_facet DUKE-NUS MEDICAL SCHOOL
Decroly E.
Debarnot C.
Ferron F.
Bouvet M.
Coutard B.
Imbert I.
Gluais L.
Papageorgiou N.
Sharff A.
Bricogne G.
Ortiz-Lombardia M.
Lescar J.
Canard B.
format Article
author Decroly E.
Debarnot C.
Ferron F.
Bouvet M.
Coutard B.
Imbert I.
Gluais L.
Papageorgiou N.
Sharff A.
Bricogne G.
Ortiz-Lombardia M.
Lescar J.
Canard B.
author_sort Decroly E.
title Crystal structure and functional analysis of the SARS-coronavirus RNA cap 2′-o-methyltransferase nsp10/nsp16 complex
title_short Crystal structure and functional analysis of the SARS-coronavirus RNA cap 2′-o-methyltransferase nsp10/nsp16 complex
title_full Crystal structure and functional analysis of the SARS-coronavirus RNA cap 2′-o-methyltransferase nsp10/nsp16 complex
title_fullStr Crystal structure and functional analysis of the SARS-coronavirus RNA cap 2′-o-methyltransferase nsp10/nsp16 complex
title_full_unstemmed Crystal structure and functional analysis of the SARS-coronavirus RNA cap 2′-o-methyltransferase nsp10/nsp16 complex
title_sort crystal structure and functional analysis of the sars-coronavirus rna cap 2′-o-methyltransferase nsp10/nsp16 complex
publisher Public Library of Science
publishDate 2020
url https://scholarbank.nus.edu.sg/handle/10635/165412
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