Antibodies targeting the PfRH1 binding domain inhibit invasion of Plasmodium falciparum merozoites

• Main Authors: Gao X., Yeo K.P., Aw S.S., Kuss C., Iyer J.K., Genesan S., Rajamanonmani R., Lescar J., Bozdech Z., Preiser P.R.
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: Public Library of Science 2020
• Subjects: antibody; binding protein; protein; protein pfrh1; cell adhesion molecule; cell surface receptor; Duffy antigen binding protein, Plasmodium; parasite antigen; protozoal protein; protozoon antibody; recombinant protein; RH1 protein, Plasmodium falciparum; animal cell; article; controlled study; merozoite; multigene family; nonhuman; parasite virulence; Plasmodium falciparum; protein analysis; protein domain; protein expression; animal; binding site; blood; cell strain COS1; Cercopithecus; chemistry; circular dichroism; erythrocyte; gene expression regulation; gene silencing; host parasite interaction; immunology; metabolism; parasitology; pathogenicity; physiology; Animals; Antibodies, Protozoan; Antigens, Protozoan; Binding Sites; Cell Adhesion Molecules; Cercopithecus aethiops; Circular Dichroism; COS Cells; Erythrocytes; Gene Expression Regulation; Gene Silencing; Host-Parasite Interactions; Merozoites; Protozoan Proteins; Receptors, Cell Surface; Recombinant Proteins
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/165424
• Institution: National University of Singapore

10.1371/journal.ppat.1000104