Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis

10.1371/journal.pmed.0050054

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Main Authors:	Heazlewood C.K., Cook M.C., Eri R., Price G.R., Tauro S.B., Taupin D., Thornton D.J., Chin W.P., Crockford T.L., Cornall R.J., Adams R., Kato M., Nelms K.A., Hong N.A., Florin T.H.J., Goodnow C.C., McGuckin M.A.
Format:	Article
Published:	Public Library of Science 2020
Subjects:	ethylnitrosourea gamma interferon interleukin 13 interleukin 1beta mucin 2 toxin tumor necrosis factor alpha MUC2 protein, human Muc2 protein, mouse mucin protein precursor animal experiment animal tissue apoptosis article cell culture clinical article colitis colon controlled study cytokine production diarrhea disease predisposition disease severity endoplasmic reticulum stress enteritis female gene expression goblet cell histopathology human human tissue immunofluorescence immunohistochemistry intestine mucosa permeability leukocyte male mesentery lymph node missense mutation mouse mouse strain nonhuman nucleotide sequence oligomerization phenotype protein assembly protein expression protein synthesis scoring system ulcerative colitis ultrastructure Western blotting wound healing adult animal C57BL mouse cell proliferation chemistry endoplasmic reticulum gene expression regulation genetic predisposition genetics immunology inflammation intestine mucosa metabolism middle aged mutation pathology protein folding protein quaternary structure Adult Animals Apoptosis Cell Proliferation Colitis, Ulcerative Endoplasmic Reticulum Gene Expression Regulation Genetic Predisposition to Disease Goblet Cells Humans Inflammation Intestinal Mucosa Male Mice Mice, Inbred C57BL Middle Aged Mucin-2 Mucins Mutation Protein Folding Protein Precursors Protein Structure, Quaternary
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/165425
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1654252023-10-31T20:50:46Z Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis Heazlewood C.K. Cook M.C. Eri R. Price G.R. Tauro S.B. Taupin D. Thornton D.J. Chin W.P. Crockford T.L. Cornall R.J. Adams R. Kato M. Nelms K.A. Hong N.A. Florin T.H.J. Goodnow C.C. McGuckin M.A. ethylnitrosourea gamma interferon interleukin 13 interleukin 1beta mucin 2 toxin tumor necrosis factor alpha MUC2 protein, human Muc2 protein, mouse mucin mucin 2 protein precursor animal experiment animal tissue apoptosis article cell culture clinical article colitis colon controlled study cytokine production diarrhea disease predisposition disease severity endoplasmic reticulum stress enteritis female gene expression goblet cell histopathology human human tissue immunofluorescence immunohistochemistry intestine mucosa permeability leukocyte male mesentery lymph node missense mutation mouse mouse strain nonhuman nucleotide sequence oligomerization phenotype protein assembly protein expression protein synthesis scoring system ulcerative colitis ultrastructure Western blotting wound healing adult animal C57BL mouse cell proliferation chemistry endoplasmic reticulum gene expression regulation genetic predisposition genetics immunology inflammation intestine mucosa metabolism middle aged mutation pathology protein folding protein quaternary structure ulcerative colitis Adult Animals Apoptosis Cell Proliferation Colitis, Ulcerative Endoplasmic Reticulum Gene Expression Regulation Genetic Predisposition to Disease Goblet Cells Humans Inflammation Intestinal Mucosa Male Mice Mice, Inbred C57BL Middle Aged Mucin-2 Mucins Mutation Protein Folding Protein Precursors Protein Structure, Quaternary 10.1371/journal.pmed.0050054 PLoS Medicine 5 3 440-460 2020-03-13T05:28:02Z 2020-03-13T05:28:02Z 2008 Article Heazlewood C.K., Cook M.C., Eri R., Price G.R., Tauro S.B., Taupin D., Thornton D.J., Chin W.P., Crockford T.L., Cornall R.J., Adams R., Kato M., Nelms K.A., Hong N.A., Florin T.H.J., Goodnow C.C., McGuckin M.A. (2008). Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis. PLoS Medicine 5 (3) : 440-460. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pmed.0050054 15491277 https://scholarbank.nus.edu.sg/handle/10635/165425 Public Library of Science Unpaywall 20200320
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	ethylnitrosourea gamma interferon interleukin 13 interleukin 1beta mucin 2 toxin tumor necrosis factor alpha MUC2 protein, human Muc2 protein, mouse mucin mucin 2 protein precursor animal experiment animal tissue apoptosis article cell culture clinical article colitis colon controlled study cytokine production diarrhea disease predisposition disease severity endoplasmic reticulum stress enteritis female gene expression goblet cell histopathology human human tissue immunofluorescence immunohistochemistry intestine mucosa permeability leukocyte male mesentery lymph node missense mutation mouse mouse strain nonhuman nucleotide sequence oligomerization phenotype protein assembly protein expression protein synthesis scoring system ulcerative colitis ultrastructure Western blotting wound healing adult animal C57BL mouse cell proliferation chemistry endoplasmic reticulum gene expression regulation genetic predisposition genetics immunology inflammation intestine mucosa metabolism middle aged mutation pathology protein folding protein quaternary structure ulcerative colitis Adult Animals Apoptosis Cell Proliferation Colitis, Ulcerative Endoplasmic Reticulum Gene Expression Regulation Genetic Predisposition to Disease Goblet Cells Humans Inflammation Intestinal Mucosa Male Mice Mice, Inbred C57BL Middle Aged Mucin-2 Mucins Mutation Protein Folding Protein Precursors Protein Structure, Quaternary
spellingShingle	ethylnitrosourea gamma interferon interleukin 13 interleukin 1beta mucin 2 toxin tumor necrosis factor alpha MUC2 protein, human Muc2 protein, mouse mucin mucin 2 protein precursor animal experiment animal tissue apoptosis article cell culture clinical article colitis colon controlled study cytokine production diarrhea disease predisposition disease severity endoplasmic reticulum stress enteritis female gene expression goblet cell histopathology human human tissue immunofluorescence immunohistochemistry intestine mucosa permeability leukocyte male mesentery lymph node missense mutation mouse mouse strain nonhuman nucleotide sequence oligomerization phenotype protein assembly protein expression protein synthesis scoring system ulcerative colitis ultrastructure Western blotting wound healing adult animal C57BL mouse cell proliferation chemistry endoplasmic reticulum gene expression regulation genetic predisposition genetics immunology inflammation intestine mucosa metabolism middle aged mutation pathology protein folding protein quaternary structure ulcerative colitis Adult Animals Apoptosis Cell Proliferation Colitis, Ulcerative Endoplasmic Reticulum Gene Expression Regulation Genetic Predisposition to Disease Goblet Cells Humans Inflammation Intestinal Mucosa Male Mice Mice, Inbred C57BL Middle Aged Mucin-2 Mucins Mutation Protein Folding Protein Precursors Protein Structure, Quaternary Heazlewood C.K. Cook M.C. Eri R. Price G.R. Tauro S.B. Taupin D. Thornton D.J. Chin W.P. Crockford T.L. Cornall R.J. Adams R. Kato M. Nelms K.A. Hong N.A. Florin T.H.J. Goodnow C.C. McGuckin M.A. Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis
description	10.1371/journal.pmed.0050054
format	Article
author	Heazlewood C.K. Cook M.C. Eri R. Price G.R. Tauro S.B. Taupin D. Thornton D.J. Chin W.P. Crockford T.L. Cornall R.J. Adams R. Kato M. Nelms K.A. Hong N.A. Florin T.H.J. Goodnow C.C. McGuckin M.A.
author_facet	Heazlewood C.K. Cook M.C. Eri R. Price G.R. Tauro S.B. Taupin D. Thornton D.J. Chin W.P. Crockford T.L. Cornall R.J. Adams R. Kato M. Nelms K.A. Hong N.A. Florin T.H.J. Goodnow C.C. McGuckin M.A.
author_sort	Heazlewood C.K.
title	Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis
title_short	Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis
title_full	Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis
title_fullStr	Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis
title_full_unstemmed	Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis
title_sort	aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis
publisher	Public Library of Science
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/165425
_version_	1781791939605037056

Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis

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