Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis

• Main Authors: Heazlewood C.K., Cook M.C., Eri R., Price G.R., Tauro S.B., Taupin D., Thornton D.J., Chin W.P., Crockford T.L., Cornall R.J., Adams R., Kato M., Nelms K.A., Hong N.A., Florin T.H.J., Goodnow C.C., McGuckin M.A.
• Format: Article
• Published: Public Library of Science 2020
• Subjects: ethylnitrosourea; gamma interferon; interleukin 13; interleukin 1beta; mucin 2; toxin; tumor necrosis factor alpha; MUC2 protein, human; Muc2 protein, mouse; mucin; protein precursor; animal experiment; animal tissue; apoptosis; article; cell culture; clinical article; colitis; colon; controlled study; cytokine production; diarrhea; disease predisposition; disease severity; endoplasmic reticulum stress; enteritis; female; gene expression; goblet cell; histopathology; human; human tissue; immunofluorescence; immunohistochemistry; intestine mucosa permeability; leukocyte; male; mesentery lymph node; missense mutation; mouse; mouse strain; nonhuman; nucleotide sequence; oligomerization; phenotype; protein assembly; protein expression; protein synthesis; scoring system; ulcerative colitis; ultrastructure; Western blotting; wound healing; adult; animal; C57BL mouse; cell proliferation; chemistry; endoplasmic reticulum; gene expression regulation; genetic predisposition; genetics; immunology; inflammation; intestine mucosa; metabolism; middle aged; mutation; pathology; protein folding; protein quaternary structure; Adult; Animals; Apoptosis; Cell Proliferation; Colitis, Ulcerative; Endoplasmic Reticulum; Gene Expression Regulation; Genetic Predisposition to Disease; Goblet Cells; Humans; Inflammation; Intestinal Mucosa; Male; Mice; Mice, Inbred C57BL; Middle Aged; Mucin-2; Mucins; Mutation; Protein Folding; Protein Precursors; Protein Structure, Quaternary
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/165425
• Institution: National University of Singapore

10.1371/journal.pmed.0050054