MiR-34a repression in proneural malignant gliomas upregulates expression of its target PDGFRA and promotes tumorigenesis

• Main Authors: Silber J., Jacobsen A., Ozawa T., Harinath G., Pedraza A., Sander C., Holland E.C., Huse J.T.
• Other Authors: DEPT OF COMPUTER SCIENCE
• Format: Article
• Published: Public Library of Science 2020
• Subjects: microRNA; microRNA 34a; platelet derived growth factor; platelet derived growth factor alpha receptor; protein p53; unclassified drug; animal experiment; animal model; article; bioinformatics; carcinogenesis; cell growth; cell proliferation; controlled study; down regulation; gene regulatory network; glioblastoma; glioma cell; growth inhibition; human; human tissue; in vitro study; in vivo study; male; mouse; negative feedback; nonhuman; Animals; Base Sequence; Cell Cycle Checkpoints; Cell Line; Cell Proliferation; Cell Transformation, Neoplastic; Gene Expression Regulation, Neoplastic; Glioma; Humans; Mice; MicroRNAs; Platelet-Derived Growth Factor; Receptor, Platelet-Derived Growth Factor alpha; Signal Transduction; Tumor Suppressor Protein p53
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/165575
• Institution: National University of Singapore

10.1371/journal.pone.0033844