Inhibition of the mitochondrial enzyme ABAD restores the amyloid-β-mediated deregulation of estradiol

• Main Authors: Lim Y.-A., Grimm A., Giese M., Mensah-Nyagan A.G., Villafranca J.E., Ittner L.M., Eckert A., G?tz J.
• Other Authors: DEPT OF PHARMACOLOGY
• Format: Article
• Published: Public Library of Science 2020
• Subjects: ag 18051; amylin; amyloid beta binding alcohol dehydrogenase; amyloid beta protein[1-42]; enzyme inhibitor; estradiol; lactate dehydrogenase; mitochondrial enzyme; reactive oxygen metabolite; tetrazolium; unclassified drug; 3 hydroxyacyl coenzyme A dehydrogenase; amyloid beta protein; amyloid beta protein (1 42); amyloid beta-protein (1-42); HSD17B10 protein, human; peptide fragment; Alzheimer disease; article; controlled study; disorders of mitochondrial functions; down regulation; drug mechanism; enzyme activity; enzyme inhibition; enzyme release; human; human cell; mitochondrial respiration; neuroblastoma cell; neurotoxicity; non insulin dependent diabetes mellitus; oxidative stress; pathogenesis; protein aggregation; protein function; protein protein interaction; regulatory mechanism; cell line; cell protection; cell respiration; cell survival; chemistry; drug effect; enzymology; metabolism; mitochondrion; oxidative phosphorylation; oxygen consumption; protein binding; 3-Hydroxyacyl CoA Dehydrogenases; Amyloid beta-Peptides; Cell Line; Cell Respiration; Cell Survival; Cytoprotection; Down-Regulation; Enzyme Inhibitors; Estradiol; Humans; Islet Amyloid Polypeptide; Mitochondria; Oxidative Phosphorylation; Oxygen Consumption; Peptide Fragments; Protein Binding; Reactive Oxygen Species
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/165582
• Institution: National University of Singapore

10.1371/journal.pone.0028887