Inhibition of the mitochondrial enzyme ABAD restores the amyloid-β-mediated deregulation of estradiol

10.1371/journal.pone.0028887

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Main Authors:	Lim Y.-A., Grimm A., Giese M., Mensah-Nyagan A.G., Villafranca J.E., Ittner L.M., Eckert A., G?tz J.
Other Authors:	DEPT OF PHARMACOLOGY
Format:	Article
Published:	Public Library of Science 2020
Subjects:	ag 18051 amylin amyloid beta binding alcohol dehydrogenase amyloid beta protein[1-42] enzyme inhibitor estradiol lactate dehydrogenase mitochondrial enzyme reactive oxygen metabolite tetrazolium unclassified drug 3 hydroxyacyl coenzyme A dehydrogenase amyloid beta protein amyloid beta protein (1 42) amyloid beta-protein (1-42) HSD17B10 protein, human peptide fragment Alzheimer disease article controlled study disorders of mitochondrial functions down regulation drug mechanism enzyme activity enzyme inhibition enzyme release human human cell mitochondrial respiration neuroblastoma cell neurotoxicity non insulin dependent diabetes mellitus oxidative stress pathogenesis protein aggregation protein function protein protein interaction regulatory mechanism cell line cell protection cell respiration cell survival chemistry drug effect enzymology metabolism mitochondrion oxidative phosphorylation oxygen consumption protein binding 3-Hydroxyacyl CoA Dehydrogenases Amyloid beta-Peptides Cell Line Cell Respiration Cell Survival Cytoprotection Down-Regulation Enzyme Inhibitors Estradiol Humans Islet Amyloid Polypeptide Mitochondria Oxidative Phosphorylation Oxygen Consumption Peptide Fragments Protein Binding Reactive Oxygen Species
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/165582
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1655822023-11-01T08:29:16Z Inhibition of the mitochondrial enzyme ABAD restores the amyloid-β-mediated deregulation of estradiol Lim Y.-A. Grimm A. Giese M. Mensah-Nyagan A.G. Villafranca J.E. Ittner L.M. Eckert A. G?tz J. DEPT OF PHARMACOLOGY ag 18051 amylin amyloid beta binding alcohol dehydrogenase amyloid beta protein[1-42] enzyme inhibitor estradiol lactate dehydrogenase mitochondrial enzyme reactive oxygen metabolite tetrazolium unclassified drug 3 hydroxyacyl coenzyme A dehydrogenase amyloid beta protein amyloid beta protein (1 42) amyloid beta-protein (1-42) estradiol HSD17B10 protein, human peptide fragment reactive oxygen metabolite Alzheimer disease article controlled study disorders of mitochondrial functions down regulation drug mechanism enzyme activity enzyme inhibition enzyme release human human cell mitochondrial respiration neuroblastoma cell neurotoxicity non insulin dependent diabetes mellitus oxidative stress pathogenesis protein aggregation protein function protein protein interaction regulatory mechanism cell line cell protection cell respiration cell survival chemistry drug effect enzymology metabolism mitochondrion oxidative phosphorylation oxygen consumption protein binding 3-Hydroxyacyl CoA Dehydrogenases Amyloid beta-Peptides Cell Line Cell Respiration Cell Survival Cytoprotection Down-Regulation Enzyme Inhibitors Estradiol Humans Islet Amyloid Polypeptide Mitochondria Oxidative Phosphorylation Oxygen Consumption Peptide Fragments Protein Binding Reactive Oxygen Species 10.1371/journal.pone.0028887 PLoS ONE 6 12 e28887 2020-03-18T05:47:48Z 2020-03-18T05:47:48Z 2011 Article Lim Y.-A., Grimm A., Giese M., Mensah-Nyagan A.G., Villafranca J.E., Ittner L.M., Eckert A., G?tz J. (2011). Inhibition of the mitochondrial enzyme ABAD restores the amyloid-β-mediated deregulation of estradiol. PLoS ONE 6 (12) : e28887. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0028887 19326203 https://scholarbank.nus.edu.sg/handle/10635/165582 Public Library of Science Unpaywall 20200320
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	ag 18051 amylin amyloid beta binding alcohol dehydrogenase amyloid beta protein[1-42] enzyme inhibitor estradiol lactate dehydrogenase mitochondrial enzyme reactive oxygen metabolite tetrazolium unclassified drug 3 hydroxyacyl coenzyme A dehydrogenase amyloid beta protein amyloid beta protein (1 42) amyloid beta-protein (1-42) estradiol HSD17B10 protein, human peptide fragment reactive oxygen metabolite Alzheimer disease article controlled study disorders of mitochondrial functions down regulation drug mechanism enzyme activity enzyme inhibition enzyme release human human cell mitochondrial respiration neuroblastoma cell neurotoxicity non insulin dependent diabetes mellitus oxidative stress pathogenesis protein aggregation protein function protein protein interaction regulatory mechanism cell line cell protection cell respiration cell survival chemistry drug effect enzymology metabolism mitochondrion oxidative phosphorylation oxygen consumption protein binding 3-Hydroxyacyl CoA Dehydrogenases Amyloid beta-Peptides Cell Line Cell Respiration Cell Survival Cytoprotection Down-Regulation Enzyme Inhibitors Estradiol Humans Islet Amyloid Polypeptide Mitochondria Oxidative Phosphorylation Oxygen Consumption Peptide Fragments Protein Binding Reactive Oxygen Species
spellingShingle	ag 18051 amylin amyloid beta binding alcohol dehydrogenase amyloid beta protein[1-42] enzyme inhibitor estradiol lactate dehydrogenase mitochondrial enzyme reactive oxygen metabolite tetrazolium unclassified drug 3 hydroxyacyl coenzyme A dehydrogenase amyloid beta protein amyloid beta protein (1 42) amyloid beta-protein (1-42) estradiol HSD17B10 protein, human peptide fragment reactive oxygen metabolite Alzheimer disease article controlled study disorders of mitochondrial functions down regulation drug mechanism enzyme activity enzyme inhibition enzyme release human human cell mitochondrial respiration neuroblastoma cell neurotoxicity non insulin dependent diabetes mellitus oxidative stress pathogenesis protein aggregation protein function protein protein interaction regulatory mechanism cell line cell protection cell respiration cell survival chemistry drug effect enzymology metabolism mitochondrion oxidative phosphorylation oxygen consumption protein binding 3-Hydroxyacyl CoA Dehydrogenases Amyloid beta-Peptides Cell Line Cell Respiration Cell Survival Cytoprotection Down-Regulation Enzyme Inhibitors Estradiol Humans Islet Amyloid Polypeptide Mitochondria Oxidative Phosphorylation Oxygen Consumption Peptide Fragments Protein Binding Reactive Oxygen Species Lim Y.-A. Grimm A. Giese M. Mensah-Nyagan A.G. Villafranca J.E. Ittner L.M. Eckert A. G?tz J. Inhibition of the mitochondrial enzyme ABAD restores the amyloid-β-mediated deregulation of estradiol
description	10.1371/journal.pone.0028887
author2	DEPT OF PHARMACOLOGY
author_facet	DEPT OF PHARMACOLOGY Lim Y.-A. Grimm A. Giese M. Mensah-Nyagan A.G. Villafranca J.E. Ittner L.M. Eckert A. G?tz J.
format	Article
author	Lim Y.-A. Grimm A. Giese M. Mensah-Nyagan A.G. Villafranca J.E. Ittner L.M. Eckert A. G?tz J.
author_sort	Lim Y.-A.
title	Inhibition of the mitochondrial enzyme ABAD restores the amyloid-β-mediated deregulation of estradiol
title_short	Inhibition of the mitochondrial enzyme ABAD restores the amyloid-β-mediated deregulation of estradiol
title_full	Inhibition of the mitochondrial enzyme ABAD restores the amyloid-β-mediated deregulation of estradiol
title_fullStr	Inhibition of the mitochondrial enzyme ABAD restores the amyloid-β-mediated deregulation of estradiol
title_full_unstemmed	Inhibition of the mitochondrial enzyme ABAD restores the amyloid-β-mediated deregulation of estradiol
title_sort	inhibition of the mitochondrial enzyme abad restores the amyloid-β-mediated deregulation of estradiol
publisher	Public Library of Science
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/165582
_version_	1781791942986694656

Inhibition of the mitochondrial enzyme ABAD restores the amyloid-β-mediated deregulation of estradiol

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