MicroRNA 144 impairs insulin signaling by inhibiting the expression of insulin receptor substrate 1 in type 2 diabetes mellitus

• Main Authors: Karolina D.S., Armugam A., Tavintharan S., Wong M.T.K., Lim S.C., Sum C.F., Jeyaseelan K.
• Other Authors: DEPT OF BIOCHEMISTRY
• Format: Article
• Published: Public Library of Science 2020
• Subjects: glucose; insulin; insulin receptor substrate 1; microRNA; microRNA 144; microRNA 146a; microRNA 150; microRNA 182; microRNA 192; microRNA 29a; microRNA 30d; microRNA 320a; unclassified drug; insulin receptor substrate; IRS1 protein, human; MIRN144 microRNA, human; adult; aged; animal experiment; animal model; animal tissue; article; blood sampling; clinical article; controlled study; correlation analysis; differential diagnosis; disease course; down regulation; erythropoiesis; gene expression profiling; gene expression regulation; glucose blood level; hormone inhibition; human; impaired glucose tolerance; insulin blood level; male; non insulin dependent diabetes mellitus; nonhuman; nucleotide sequence; oral glucose tolerance test; pathogenesis; protein blood level; protein function; protein localization; protein targeting; rat; RNA analysis; signal transduction; upregulation; animal; blood; disease model; DNA microarray; genetics; metabolism; physiology; real time polymerase chain reaction; validation study; Wistar rat; Rattus; Animals; Diabetes Mellitus, Type 2; Disease Models, Animal; Gene Expression Profiling; Humans; Insulin; Insulin Receptor Substrate Proteins; Male; MicroRNAs; Oligonucleotide Array Sequence Analysis; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Signal Transduction
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/165589
• Institution: National University of Singapore

10.1371/journal.pone.0022839