MicroRNA 144 impairs insulin signaling by inhibiting the expression of insulin receptor substrate 1 in type 2 diabetes mellitus

10.1371/journal.pone.0022839

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Main Authors:	Karolina D.S., Armugam A., Tavintharan S., Wong M.T.K., Lim S.C., Sum C.F., Jeyaseelan K.
Other Authors:	DEPT OF BIOCHEMISTRY
Format:	Article
Published:	Public Library of Science 2020
Subjects:	glucose insulin insulin receptor substrate 1 microRNA microRNA 144 microRNA 146a microRNA 150 microRNA 182 microRNA 192 microRNA 29a microRNA 30d microRNA 320a unclassified drug insulin receptor substrate IRS1 protein, human MIRN144 microRNA, human adult aged animal experiment animal model animal tissue article blood sampling clinical article controlled study correlation analysis differential diagnosis disease course down regulation erythropoiesis gene expression profiling gene expression regulation glucose blood level hormone inhibition human impaired glucose tolerance insulin blood level male non insulin dependent diabetes mellitus nonhuman nucleotide sequence oral glucose tolerance test pathogenesis protein blood level protein function protein localization protein targeting rat RNA analysis signal transduction upregulation animal blood disease model DNA microarray genetics metabolism physiology real time polymerase chain reaction validation study Wistar rat Rattus Animals Diabetes Mellitus, Type 2 Disease Models, Animal Gene Expression Profiling Humans Insulin Insulin Receptor Substrate Proteins Male MicroRNAs Oligonucleotide Array Sequence Analysis Rats Rats, Wistar Real-Time Polymerase Chain Reaction Signal Transduction
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/165589
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1655892023-09-07T22:17:27Z MicroRNA 144 impairs insulin signaling by inhibiting the expression of insulin receptor substrate 1 in type 2 diabetes mellitus Karolina D.S. Armugam A. Tavintharan S. Wong M.T.K. Lim S.C. Sum C.F. Jeyaseelan K. DEPT OF BIOCHEMISTRY DUKE-NUS MEDICAL SCHOOL glucose insulin insulin receptor substrate 1 microRNA microRNA 144 microRNA 146a microRNA 150 microRNA 182 microRNA 192 microRNA 29a microRNA 30d microRNA 320a unclassified drug insulin insulin receptor substrate IRS1 protein, human microRNA MIRN144 microRNA, human adult aged animal experiment animal model animal tissue article blood sampling clinical article controlled study correlation analysis differential diagnosis disease course down regulation erythropoiesis gene expression profiling gene expression regulation glucose blood level hormone inhibition human impaired glucose tolerance insulin blood level male non insulin dependent diabetes mellitus nonhuman nucleotide sequence oral glucose tolerance test pathogenesis protein blood level protein function protein localization protein targeting rat RNA analysis signal transduction upregulation animal blood disease model DNA microarray genetics metabolism non insulin dependent diabetes mellitus physiology real time polymerase chain reaction signal transduction validation study Wistar rat Rattus Animals Diabetes Mellitus, Type 2 Disease Models, Animal Gene Expression Profiling Humans Insulin Insulin Receptor Substrate Proteins Male MicroRNAs Oligonucleotide Array Sequence Analysis Rats Rats, Wistar Real-Time Polymerase Chain Reaction Signal Transduction 10.1371/journal.pone.0022839 PLoS ONE 6 8 e22839 2020-03-18T05:49:24Z 2020-03-18T05:49:24Z 2011 Article Karolina D.S., Armugam A., Tavintharan S., Wong M.T.K., Lim S.C., Sum C.F., Jeyaseelan K. (2011). MicroRNA 144 impairs insulin signaling by inhibiting the expression of insulin receptor substrate 1 in type 2 diabetes mellitus. PLoS ONE 6 (8) : e22839. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0022839 19326203 https://scholarbank.nus.edu.sg/handle/10635/165589 Public Library of Science Unpaywall 20200320
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	glucose insulin insulin receptor substrate 1 microRNA microRNA 144 microRNA 146a microRNA 150 microRNA 182 microRNA 192 microRNA 29a microRNA 30d microRNA 320a unclassified drug insulin insulin receptor substrate IRS1 protein, human microRNA MIRN144 microRNA, human adult aged animal experiment animal model animal tissue article blood sampling clinical article controlled study correlation analysis differential diagnosis disease course down regulation erythropoiesis gene expression profiling gene expression regulation glucose blood level hormone inhibition human impaired glucose tolerance insulin blood level male non insulin dependent diabetes mellitus nonhuman nucleotide sequence oral glucose tolerance test pathogenesis protein blood level protein function protein localization protein targeting rat RNA analysis signal transduction upregulation animal blood disease model DNA microarray genetics metabolism non insulin dependent diabetes mellitus physiology real time polymerase chain reaction signal transduction validation study Wistar rat Rattus Animals Diabetes Mellitus, Type 2 Disease Models, Animal Gene Expression Profiling Humans Insulin Insulin Receptor Substrate Proteins Male MicroRNAs Oligonucleotide Array Sequence Analysis Rats Rats, Wistar Real-Time Polymerase Chain Reaction Signal Transduction
spellingShingle	glucose insulin insulin receptor substrate 1 microRNA microRNA 144 microRNA 146a microRNA 150 microRNA 182 microRNA 192 microRNA 29a microRNA 30d microRNA 320a unclassified drug insulin insulin receptor substrate IRS1 protein, human microRNA MIRN144 microRNA, human adult aged animal experiment animal model animal tissue article blood sampling clinical article controlled study correlation analysis differential diagnosis disease course down regulation erythropoiesis gene expression profiling gene expression regulation glucose blood level hormone inhibition human impaired glucose tolerance insulin blood level male non insulin dependent diabetes mellitus nonhuman nucleotide sequence oral glucose tolerance test pathogenesis protein blood level protein function protein localization protein targeting rat RNA analysis signal transduction upregulation animal blood disease model DNA microarray genetics metabolism non insulin dependent diabetes mellitus physiology real time polymerase chain reaction signal transduction validation study Wistar rat Rattus Animals Diabetes Mellitus, Type 2 Disease Models, Animal Gene Expression Profiling Humans Insulin Insulin Receptor Substrate Proteins Male MicroRNAs Oligonucleotide Array Sequence Analysis Rats Rats, Wistar Real-Time Polymerase Chain Reaction Signal Transduction Karolina D.S. Armugam A. Tavintharan S. Wong M.T.K. Lim S.C. Sum C.F. Jeyaseelan K. MicroRNA 144 impairs insulin signaling by inhibiting the expression of insulin receptor substrate 1 in type 2 diabetes mellitus
description	10.1371/journal.pone.0022839
author2	DEPT OF BIOCHEMISTRY
author_facet	DEPT OF BIOCHEMISTRY Karolina D.S. Armugam A. Tavintharan S. Wong M.T.K. Lim S.C. Sum C.F. Jeyaseelan K.
format	Article
author	Karolina D.S. Armugam A. Tavintharan S. Wong M.T.K. Lim S.C. Sum C.F. Jeyaseelan K.
author_sort	Karolina D.S.
title	MicroRNA 144 impairs insulin signaling by inhibiting the expression of insulin receptor substrate 1 in type 2 diabetes mellitus
title_short	MicroRNA 144 impairs insulin signaling by inhibiting the expression of insulin receptor substrate 1 in type 2 diabetes mellitus
title_full	MicroRNA 144 impairs insulin signaling by inhibiting the expression of insulin receptor substrate 1 in type 2 diabetes mellitus
title_fullStr	MicroRNA 144 impairs insulin signaling by inhibiting the expression of insulin receptor substrate 1 in type 2 diabetes mellitus
title_full_unstemmed	MicroRNA 144 impairs insulin signaling by inhibiting the expression of insulin receptor substrate 1 in type 2 diabetes mellitus
title_sort	microrna 144 impairs insulin signaling by inhibiting the expression of insulin receptor substrate 1 in type 2 diabetes mellitus
publisher	Public Library of Science
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/165589
_version_	1778169270155345920

MicroRNA 144 impairs insulin signaling by inhibiting the expression of insulin receptor substrate 1 in type 2 diabetes mellitus

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