Validation of the 18-gene classifier as a prognostic biomarker of distant metastasis in breast cancer

• Main Authors: Cheng, S.H.-C, Huang, T.-T, Cheng, Y.-H., Tan, T.B.K., Horng, C.-F., Wang, Y.A., Brian, N.S., Shih, L.-S., Yu, B.-L.
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: Public Library of Science 2020
• Subjects: chemokine receptor CCR1; matrix metalloproteinase 15; protein kinase Pim 1; transcription factor 7 like 1; vanilloid receptor 6; tumor marker; adult; Article; BLM gene; breast cancer; breast surgery; BUB1B gene; C16ORF7 gene; cancer prognosis; cancer staging; CCNB1 gene; CCR1 gene; classifier; DDX39 gene; distant metastasis; DTX2 gene; ENSA gene; external validity; gene; gene classifier; genetic algorithm; high risk patient; human; human tissue; internal validity; low risk patient; major clinical study; MMP15 gene; NFATC2IP gene; OBSL1 gene; PIM1 gene; probability; PTI1 gene; RCHY1 gene; risk assessment; scoring system; STIL gene; TCF3 gene; TPX2 gene; TRPV6 gene; aged; Breast Neoplasms; cancer grading; female; gene expression profiling; genetics; metastasis; middle aged; mortality; multimodality cancer therapy; pathology; prognosis; proportional hazards model; reproducibility; young adult; Adult; Aged; Biomarkers, Tumor; Combined Modality Therapy; Female; Gene Expression Profiling; Humans; Middle Aged; Neoplasm Grading; Neoplasm Metastasis; Neoplasm Staging; Prognosis; Proportional Hazards Models; Reproducibility of Results; Young Adult
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/165779
• Institution: National University of Singapore

10.1371/journal.pone.0184372