Fatty acid synthase mediates EGFR palmitoylation in EGFR mutated non-small cell lung cancer

10.15252/emmm.201708313

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Main Authors:	Ali, A, Levantini, E, Teo, J.T, Goggi, J, Clohessy, J.G, Wu, C.S, Chen, L, Yang, H, Krishnan, I, Kocher, O, Zhang, J, Soo, R.A, Bhakoo, K, Chin, T.M, Tenen, D.G
Other Authors:	CANCER SCIENCE INSTITUTE OF SINGAPORE
Format:	Article
Published:	2020
Subjects:	epidermal growth factor receptor fatty acid synthase gefitinib protein tyrosine kinase inhibitor tetrahydrolipstatin EGFR protein, human fatty acid protein kinase B protein kinase inhibitor animal cell animal experiment animal model antineoplastic activity Article cancer inhibition cell cycle cell proliferation cell viability controlled study enzyme inhibition fatty acid metabolism female human human cell in vivo study male mouse non small cell lung cancer nonhuman palmitoylation priority journal signal transduction transgenic mouse tumor resistance tumor volume tumor xenograft ubiquitination animal antagonists and inhibitors biological model drug effect drug resistance drug screening gene expression regulation gene silencing genetics lipoylation lung tumor metabolism mutation pathology tumor cell line upregulation Animals Carcinoma, Non-Small-Cell Lung Cell Line, Tumor Cell Proliferation Drug Resistance, Neoplasm ErbB Receptors Fatty Acid Synthases Fatty Acids Gene Expression Regulation, Neoplastic Gene Silencing Lipoylation Lung Neoplasms Male Mice, Transgenic Models, Biological Mutation Orlistat Protein Kinase Inhibitors Proto-Oncogene Proteins c-akt Signal Transduction Ubiquitination Up-Regulation Xenograft Model Antitumor Assays
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/173737
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1737372024-05-08T09:51:46Z Fatty acid synthase mediates EGFR palmitoylation in EGFR mutated non-small cell lung cancer Ali, A Levantini, E Teo, J.T Goggi, J Clohessy, J.G Wu, C.S Chen, L Yang, H Krishnan, I Kocher, O Zhang, J Soo, R.A Bhakoo, K Chin, T.M Tenen, D.G CANCER SCIENCE INSTITUTE OF SINGAPORE PHYSIOLOGY ANATOMY BIOCHEMISTRY MEDICINE epidermal growth factor receptor fatty acid synthase gefitinib protein tyrosine kinase inhibitor tetrahydrolipstatin EGFR protein, human epidermal growth factor receptor fatty acid fatty acid synthase protein kinase B protein kinase inhibitor tetrahydrolipstatin animal cell animal experiment animal model antineoplastic activity Article cancer inhibition cell cycle cell proliferation cell viability controlled study enzyme inhibition fatty acid metabolism female human human cell in vivo study male mouse non small cell lung cancer nonhuman palmitoylation priority journal signal transduction transgenic mouse tumor resistance tumor volume tumor xenograft ubiquitination animal antagonists and inhibitors biological model drug effect drug resistance drug screening gene expression regulation gene silencing genetics lipoylation lung tumor metabolism mutation non small cell lung cancer pathology tumor cell line upregulation Animals Carcinoma, Non-Small-Cell Lung Cell Line, Tumor Cell Proliferation Drug Resistance, Neoplasm ErbB Receptors Fatty Acid Synthases Fatty Acids Gene Expression Regulation, Neoplastic Gene Silencing Lipoylation Lung Neoplasms Male Mice, Transgenic Models, Biological Mutation Orlistat Protein Kinase Inhibitors Proto-Oncogene Proteins c-akt Signal Transduction Ubiquitination Up-Regulation Xenograft Model Antitumor Assays 10.15252/emmm.201708313 EMBO Molecular Medicine 10 3 e8313 2020-09-01T00:45:01Z 2020-09-01T00:45:01Z 2018 Article Ali, A, Levantini, E, Teo, J.T, Goggi, J, Clohessy, J.G, Wu, C.S, Chen, L, Yang, H, Krishnan, I, Kocher, O, Zhang, J, Soo, R.A, Bhakoo, K, Chin, T.M, Tenen, D.G (2018). Fatty acid synthase mediates EGFR palmitoylation in EGFR mutated non-small cell lung cancer. EMBO Molecular Medicine 10 (3) : e8313. ScholarBank@NUS Repository. https://doi.org/10.15252/emmm.201708313 17574676 https://scholarbank.nus.edu.sg/handle/10635/173737 Unpaywall 20200831
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	epidermal growth factor receptor fatty acid synthase gefitinib protein tyrosine kinase inhibitor tetrahydrolipstatin EGFR protein, human epidermal growth factor receptor fatty acid fatty acid synthase protein kinase B protein kinase inhibitor tetrahydrolipstatin animal cell animal experiment animal model antineoplastic activity Article cancer inhibition cell cycle cell proliferation cell viability controlled study enzyme inhibition fatty acid metabolism female human human cell in vivo study male mouse non small cell lung cancer nonhuman palmitoylation priority journal signal transduction transgenic mouse tumor resistance tumor volume tumor xenograft ubiquitination animal antagonists and inhibitors biological model drug effect drug resistance drug screening gene expression regulation gene silencing genetics lipoylation lung tumor metabolism mutation non small cell lung cancer pathology tumor cell line upregulation Animals Carcinoma, Non-Small-Cell Lung Cell Line, Tumor Cell Proliferation Drug Resistance, Neoplasm ErbB Receptors Fatty Acid Synthases Fatty Acids Gene Expression Regulation, Neoplastic Gene Silencing Lipoylation Lung Neoplasms Male Mice, Transgenic Models, Biological Mutation Orlistat Protein Kinase Inhibitors Proto-Oncogene Proteins c-akt Signal Transduction Ubiquitination Up-Regulation Xenograft Model Antitumor Assays
spellingShingle	epidermal growth factor receptor fatty acid synthase gefitinib protein tyrosine kinase inhibitor tetrahydrolipstatin EGFR protein, human epidermal growth factor receptor fatty acid fatty acid synthase protein kinase B protein kinase inhibitor tetrahydrolipstatin animal cell animal experiment animal model antineoplastic activity Article cancer inhibition cell cycle cell proliferation cell viability controlled study enzyme inhibition fatty acid metabolism female human human cell in vivo study male mouse non small cell lung cancer nonhuman palmitoylation priority journal signal transduction transgenic mouse tumor resistance tumor volume tumor xenograft ubiquitination animal antagonists and inhibitors biological model drug effect drug resistance drug screening gene expression regulation gene silencing genetics lipoylation lung tumor metabolism mutation non small cell lung cancer pathology tumor cell line upregulation Animals Carcinoma, Non-Small-Cell Lung Cell Line, Tumor Cell Proliferation Drug Resistance, Neoplasm ErbB Receptors Fatty Acid Synthases Fatty Acids Gene Expression Regulation, Neoplastic Gene Silencing Lipoylation Lung Neoplasms Male Mice, Transgenic Models, Biological Mutation Orlistat Protein Kinase Inhibitors Proto-Oncogene Proteins c-akt Signal Transduction Ubiquitination Up-Regulation Xenograft Model Antitumor Assays Ali, A Levantini, E Teo, J.T Goggi, J Clohessy, J.G Wu, C.S Chen, L Yang, H Krishnan, I Kocher, O Zhang, J Soo, R.A Bhakoo, K Chin, T.M Tenen, D.G Fatty acid synthase mediates EGFR palmitoylation in EGFR mutated non-small cell lung cancer
description	10.15252/emmm.201708313
author2	CANCER SCIENCE INSTITUTE OF SINGAPORE
author_facet	CANCER SCIENCE INSTITUTE OF SINGAPORE Ali, A Levantini, E Teo, J.T Goggi, J Clohessy, J.G Wu, C.S Chen, L Yang, H Krishnan, I Kocher, O Zhang, J Soo, R.A Bhakoo, K Chin, T.M Tenen, D.G
format	Article
author	Ali, A Levantini, E Teo, J.T Goggi, J Clohessy, J.G Wu, C.S Chen, L Yang, H Krishnan, I Kocher, O Zhang, J Soo, R.A Bhakoo, K Chin, T.M Tenen, D.G
author_sort	Ali, A
title	Fatty acid synthase mediates EGFR palmitoylation in EGFR mutated non-small cell lung cancer
title_short	Fatty acid synthase mediates EGFR palmitoylation in EGFR mutated non-small cell lung cancer
title_full	Fatty acid synthase mediates EGFR palmitoylation in EGFR mutated non-small cell lung cancer
title_fullStr	Fatty acid synthase mediates EGFR palmitoylation in EGFR mutated non-small cell lung cancer
title_full_unstemmed	Fatty acid synthase mediates EGFR palmitoylation in EGFR mutated non-small cell lung cancer
title_sort	fatty acid synthase mediates egfr palmitoylation in egfr mutated non-small cell lung cancer
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/173737
_version_	1800914187251089408

Fatty acid synthase mediates EGFR palmitoylation in EGFR mutated non-small cell lung cancer

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