Bortezomib warhead-switch confers dual activity against mycobacterial caseinolytic protease and proteasome and selectivity against human proteasome

• Main Authors: Moreira W., Santhanakrishnan, S, Dymock, B.W, Dick, T
• Other Authors: MICROBIOLOGY AND IMMUNOLOGY
• Format: Article
• Published: 2020
• Subjects: bacterial protein; boronic acid derivative; bortezomib; endopeptidase Clp; proteasome; pyrazine; Article; bacterial growth; bactericidal activity; cell activity; controlled study; cytotoxicity; drug activity; drug selectivity; drug synthesis; enzyme inhibition assay; fluorescence analysis; minimum bactericidal concentration; minimum inhibitory concentration; MTS assay; Mycobacterium tuberculosis; nonhuman
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/173790
• Institution: National University of Singapore

10.3389/fmicb.2017.00746