Combined use of irinotecan with histone deacetylase inhibitor belinostat could cause severe toxicity by inhibiting SN-38 glucuronidation via UGT1A1

Combined use of irinotecan with histone deacetylase inhibitor belinostat could cause severe toxicity by inhibiting SN-38 glucuronidation via UGT1A1

10.18632/oncotarget.15017

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Bibliographic Details
Main Authors:	Wang, L, Chan, C.E.L, Wong, A.L.-A, Wong, F.C, Lim, S.W, Chinnathambi, A, Alharbi, S.A, Lee, L.S.-U, Soo, R, Yong, W.P, Lee, S.C, Ho, P.C.-L, Sethi, G, Goh, B.C
Other Authors:	PHARMACY
Format:	Article
Published:	2020
Subjects:	belinostat firtecan firtecan glucuronide glucuronosyltransferase 1A1 irinotecan Article controlled study drug glucuronidation enzyme inactivation enzyme inhibition heterozygote homozygote human human cell in vitro study incubation time limit of quantitation liquid chromatography-mass spectrometry liver microsome measurement accuracy measurement precision
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/173804
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Institution:	National University of Singapore

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Summary:	10.18632/oncotarget.15017