Combined use of irinotecan with histone deacetylase inhibitor belinostat could cause severe toxicity by inhibiting SN-38 glucuronidation via UGT1A1

10.18632/oncotarget.15017

Saved in:

Bibliographic Details
Main Authors:	Wang, L, Chan, C.E.L, Wong, A.L.-A, Wong, F.C, Lim, S.W, Chinnathambi, A, Alharbi, S.A, Lee, L.S.-U, Soo, R, Yong, W.P, Lee, S.C, Ho, P.C.-L, Sethi, G, Goh, B.C
Other Authors:	PHARMACY
Format:	Article
Published:	2020
Subjects:	belinostat firtecan firtecan glucuronide glucuronosyltransferase 1A1 irinotecan Article controlled study drug glucuronidation enzyme inactivation enzyme inhibition heterozygote homozygote human human cell in vitro study incubation time limit of quantitation liquid chromatography-mass spectrometry liver microsome measurement accuracy measurement precision
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/173804
Tags:	Add Tag No Tags, Be the first to tag this record!
Institution:	National University of Singapore

id	sg-nus-scholar.10635-173804
record_format	dspace
spelling	sg-nus-scholar.10635-1738042024-04-18T03:04:24Z Combined use of irinotecan with histone deacetylase inhibitor belinostat could cause severe toxicity by inhibiting SN-38 glucuronidation via UGT1A1 Wang, L Chan, C.E.L Wong, A.L.-A Wong, F.C Lim, S.W Chinnathambi, A Alharbi, S.A Lee, L.S.-U Soo, R Yong, W.P Lee, S.C Ho, P.C.-L Sethi, G Goh, B.C PHARMACY MEDICINE CANCER SCIENCE INSTITUTE OF SINGAPORE PHARMACOLOGY belinostat firtecan firtecan glucuronide glucuronosyltransferase 1A1 irinotecan Article controlled study drug glucuronidation enzyme inactivation enzyme inhibition heterozygote homozygote human human cell in vitro study incubation time limit of quantitation liquid chromatography-mass spectrometry liver microsome measurement accuracy measurement precision 10.18632/oncotarget.15017 Oncotarget 8 25 41572-41581 2020-09-01T00:58:19Z 2020-09-01T00:58:19Z 2017 Article Wang, L, Chan, C.E.L, Wong, A.L.-A, Wong, F.C, Lim, S.W, Chinnathambi, A, Alharbi, S.A, Lee, L.S.-U, Soo, R, Yong, W.P, Lee, S.C, Ho, P.C.-L, Sethi, G, Goh, B.C (2017). Combined use of irinotecan with histone deacetylase inhibitor belinostat could cause severe toxicity by inhibiting SN-38 glucuronidation via UGT1A1. Oncotarget 8 (25) : 41572-41581. ScholarBank@NUS Repository. https://doi.org/10.18632/oncotarget.15017 19492553 https://scholarbank.nus.edu.sg/handle/10635/173804 Unpaywall 20200831
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	belinostat firtecan firtecan glucuronide glucuronosyltransferase 1A1 irinotecan Article controlled study drug glucuronidation enzyme inactivation enzyme inhibition heterozygote homozygote human human cell in vitro study incubation time limit of quantitation liquid chromatography-mass spectrometry liver microsome measurement accuracy measurement precision
spellingShingle	belinostat firtecan firtecan glucuronide glucuronosyltransferase 1A1 irinotecan Article controlled study drug glucuronidation enzyme inactivation enzyme inhibition heterozygote homozygote human human cell in vitro study incubation time limit of quantitation liquid chromatography-mass spectrometry liver microsome measurement accuracy measurement precision Wang, L Chan, C.E.L Wong, A.L.-A Wong, F.C Lim, S.W Chinnathambi, A Alharbi, S.A Lee, L.S.-U Soo, R Yong, W.P Lee, S.C Ho, P.C.-L Sethi, G Goh, B.C Combined use of irinotecan with histone deacetylase inhibitor belinostat could cause severe toxicity by inhibiting SN-38 glucuronidation via UGT1A1
description	10.18632/oncotarget.15017
author2	PHARMACY
author_facet	PHARMACY Wang, L Chan, C.E.L Wong, A.L.-A Wong, F.C Lim, S.W Chinnathambi, A Alharbi, S.A Lee, L.S.-U Soo, R Yong, W.P Lee, S.C Ho, P.C.-L Sethi, G Goh, B.C
format	Article
author	Wang, L Chan, C.E.L Wong, A.L.-A Wong, F.C Lim, S.W Chinnathambi, A Alharbi, S.A Lee, L.S.-U Soo, R Yong, W.P Lee, S.C Ho, P.C.-L Sethi, G Goh, B.C
author_sort	Wang, L
title	Combined use of irinotecan with histone deacetylase inhibitor belinostat could cause severe toxicity by inhibiting SN-38 glucuronidation via UGT1A1
title_short	Combined use of irinotecan with histone deacetylase inhibitor belinostat could cause severe toxicity by inhibiting SN-38 glucuronidation via UGT1A1
title_full	Combined use of irinotecan with histone deacetylase inhibitor belinostat could cause severe toxicity by inhibiting SN-38 glucuronidation via UGT1A1
title_fullStr	Combined use of irinotecan with histone deacetylase inhibitor belinostat could cause severe toxicity by inhibiting SN-38 glucuronidation via UGT1A1
title_full_unstemmed	Combined use of irinotecan with histone deacetylase inhibitor belinostat could cause severe toxicity by inhibiting SN-38 glucuronidation via UGT1A1
title_sort	combined use of irinotecan with histone deacetylase inhibitor belinostat could cause severe toxicity by inhibiting sn-38 glucuronidation via ugt1a1
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/173804
_version_	1800914192571564032

Combined use of irinotecan with histone deacetylase inhibitor belinostat could cause severe toxicity by inhibiting SN-38 glucuronidation via UGT1A1

Similar Items